Bethany L. Kormos

Pfizer (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index1.6kcitations47works5.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Receptor Mechanisms and Signaling(8), RNA and protein synthesis mechanisms(7), Protein Structure and Dynamics(6), Phosphodiesterase function and regulation(6), Crystallization and Solubility Studies(5)

Publications47 total

Discovery of small molecule modulators of the thin filament that alter the contractile profile in a hypertrophic cardiomyopathy engineered tissue model
Journal of Biological Chemistry·2025Open Access
Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948
Journal of Medicinal Chemistry·2024· 10 cited
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism
Nature Communications·2023· 30 citedOpen Access
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels
Nature Communications·2023· 27 citedOpen Access
An inverse agonist of orphan receptor GPR61 reveals a novel allosteric mechanism
2023Open Access
Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors
Journal of Biological Chemistry·2023· 16 citedOpen Access
CCDC 2210556: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
NMR spectroscopy: the swiss army knife of drug discovery
Journal of Biomolecular NMR·2020· 17 cited
CCDC 1993705: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
Author Correction: Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs
Scientific Reports·2019Open Access
Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor
Journal of Medicinal Chemistry·2018
Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs
Scientific Reports·2018· 53 citedOpen Access
Late-Stage Microsomal Oxidation Reduces Drug–Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189
ACS Medicinal Chemistry Letters·2018· 38 citedOpen Access
Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate
Journal of Medicinal Chemistry·2018· 27 citedOpen Access
Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs
Nature Chemical Biology·2017· 175 citedOpen Access
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor
Journal of Medicinal Chemistry·2017· 32 citedOpen Access
Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects
ACS Chemical Neuroscience·2016· 23 citedOpen Access
Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK
Journal of Pharmacology and Experimental Therapeutics·2015· 37 cited
Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7 <i>H</i> -pyrrolo[2,3- <i>d</i> ]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor
Journal of Medicinal Chemistry·2014· 178 citedOpen Access
Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold
Bioorganic & Medicinal Chemistry Letters·2014· 28 citedOpen Access
page 1 of 3Next →

Frequent Co-authors

Christopher J. Cramer(12), Patrick R. Verhoest(9), Travis T. Wager(8), Rebecca E. O’Connor(8), Anne M. Baranger(7), David L. Beveridge(7), Christopher J. Helal(6), Antonia F. Stepan(5), Ethan L. Fisher(5), Edward X. Yang(5), Thomas A. Chappie(5), Christopher J. O’Donnell(4), Jaclyn L. Henderson(4), Warren D. Hirst(4), Paul Galatsis(4), Edward C. Sherer(4), Cheng Chang(4), Kimberly F. Fennell(4), Jamison B. Tuttle(4), Kevin J. Filipski(4)