Michael Beer

University of Bristol — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

6h-index101citations18works3.82yr avg
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Research Topics

Antibiotic Resistance in Bacteria(14), Antibiotics Pharmacokinetics and Efficacy(9), Protein Structure and Dynamics(2), Bacterial biofilms and quorum sensing(2), Antibiotic Use and Resistance(2)

Publications18 total

Drop on fixed target reaction initiation approach for serial and time resolved crystallography
2025Open Access
Time-resolved ligand dynamics revealed in a β-lactamase using room-temperature serial crystallography
2025Open Access
A dynamical-nonequilibrium molecular dynamics (D-NEMD) alanine scanning approach for identifying allosteric positions in proteins
2025Open Access
Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase <scp>GES</scp> ‐1 by enmetazobactam and tazobactam
FEBS Letters·2025Open Access
Mechanistic Basis for Inhibition of the Extended Spectrum Class A β-Lactamase GES-1 by Tazobactam and Enmetazobactam
2025Open Access
Electrostatic interactions influence diazabicyclooctane inhibitor potency against OXA-48-like β-lactamases
RSC Medicinal Chemistry·2025Open Access
Perturb-seq protocol v1
2024Open Access
Dynamical nonequilibrium molecular dynamics simulations reveal allosteric networks, signal transduction mechanisms, and sites associated with drug resistance in biomolecular systems
Molecular Physics·2024· 7 citedOpen Access
Electrostatic interactions define nacubactam potency against OXA-48-like β-lactamases
2024Open Access
Dynamical Responses Predict a Distal Site that Modulates Activity in an Antibiotic Resistance Enzyme
2024Open Access
Electric Fields Are a Key Determinant of Carbapenemase Activity in Class A β-Lactamases
ACS Catalysis·2024· 21 citedOpen Access
Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase
ACS Infectious Diseases·2024· 8 citedOpen Access
Dynamical responses predict a distal site that modulates activity in an antibiotic resistance enzyme
Chemical Science·2024· 13 citedOpen Access
Electric fields determine carbapenemase activity in class A β-lactamases
2023Open Access
Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase
Journal of the American Chemical Society·2023· 30 citedOpen Access
Tautomer-specific deacylation and Ω-loop flexibility explain carbapenem-hydrolyzing, broad-spectrum activity of the KPC-2 β-lactamase
2022Open Access
QM/MM Simulations Reveal the Determinants of Carbapenemase Activity in Class A β-Lactamases
ACS Infectious Diseases·2022· 21 citedOpen Access
QM/MM Simulations Reveal the Determinants of Carbapenemase Activity in Class A β-lactamases
2022· 1 citedOpen Access

Frequent Co-authors

Adrian J. Mulholland(14), James Spencer(14), Catherine L. Tooke(10), Philip Hinchliffe(9), Christopher J. Schofield(5), Marc W. van der Kamp(5), Balazs Balega(4), Marko Hanževački(3), Kirill Zinovjev(2), Charlotte K. Colenso(2), Hira Jabeen(2), H. Adrian Bunzel(2), Ewa I. Chudyk(2), Michael A. L. Limb(2), Charlotte Jones(2), A. Sofia F. Oliveira(2), Angie Tsz Yan Li(2), Joseph F. Hoff(2), Kirsty E. Goudar(2), John M. Shaw(2)