Jonathan Lippy

Bristol-Myers Squibb (Germany) — Germany

Medicine · Health Sciences

21h-index1.5kcitations50works0.02yr avg
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Research Topics

Cytokine Signaling Pathways and Interactions(8), Protein Kinase Regulation and GTPase Signaling(7), Peroxisome Proliferator-Activated Receptors(6), Myeloproliferative Neoplasms: Diagnosis and Treatment(6), Pain Mechanisms and Treatments(5)

Publications50 total

Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain
Medicinal Chemistry Research·2023· 1 citedOpen Access
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain
Journal of Medicinal Chemistry·2022· 19 citedOpen Access
Discovery of (<i>S</i>)-1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain
Journal of Medicinal Chemistry·2022· 27 citedOpen Access
Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors
Journal of Medicinal Chemistry·2022· 14 citedOpen Access
Discovery, Structure–Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain
Journal of Medicinal Chemistry·2021· 16 citedOpen Access
An innovative kinome platform to accelerate small-molecule inhibitor discovery and optimization from hits to leads
Drug Discovery Today·2021· 7 cited
Leveraging Automation toward Development of a High-Throughput Gene Expression Profiling Platform
SLAS DISCOVERY·2020· 5 citedOpen Access
Rapid Compound Integrity Assessment for High-Throughput Screening Hit Triaging
SLAS DISCOVERY·2020· 4 citedOpen Access
Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent
ACS Medicinal Chemistry Letters·2020· 27 citedOpen Access
A High-Throughput BRET Cellular Target Engagement Assay Links Biochemical to Cellular Activity for Bruton’s Tyrosine Kinase
SLAS DISCOVERY·2019· 14 citedOpen Access
Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis
ACS Medicinal Chemistry Letters·2019· 14 citedOpen Access
CCDC 1896615: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
Discovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents
ACS Medicinal Chemistry Letters·2018· 28 citedOpen Access
Conversion of carbazole carboxamide based reversible inhibitors of Bruton’s tyrosine kinase (BTK) into potent, selective irreversible inhibitors in the carbazole, tetrahydrocarbazole, and a new 2,3-dimethylindole series
Bioorganic & Medicinal Chemistry Letters·2018· 15 citedOpen Access
Miniaturized High-Throughput Multiparameter Flow Cytometry Assays Measuring In Vitro Human Dendritic Cell Maturation and T-Cell Activation in Mixed Lymphocyte Reactions
SLAS DISCOVERY·2018· 9 citedOpen Access
Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFβRI)
Bioorganic & Medicinal Chemistry·2018· 35 citedOpen Access
Leveraging the IncuCyte Technology for Higher-Throughput and Automated Chemotaxis Assays for Target Validation and Compound Characterization
SLAS DISCOVERY·2017· 12 citedOpen Access
Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders
Journal of Medicinal Chemistry·2017· 22 citedOpen Access
Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors
Bioorganic & Medicinal Chemistry Letters·2017· 13 citedOpen Access
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain
Journal of Pharmacology and Experimental Therapeutics·2016· 118 citedOpen Access
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Frequent Co-authors

John S. Tokarski(14), John S. Sack(12), John E. Macor(10), George L. Trainor(9), Louis J. Lombardo(8), R. M. Borzilleri(8), J.K. Muckelbauer(8), Andrew J. Tebben(8), Joseph Fargnoli(7), Javed Khan(7), Percy H. Carter(7), Aberra Fura(7), Walter A. Kostich(6), Brian D. Hamman(6), Carolyn D. Dzierba(6), Joanne J. Bronson(6), Ashok V. Purandare(6), Peter T. W. Cheng(6), Gary L. Schieven(6), Neha Surti(6)