Giorgio Basile

Joslin Diabetes Center — United States

Medicine · Health Sciences

13h-index690citations31works6.62yr avg
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Research Topics

Pancreatic function and diabetes(19), Metabolism, Diabetes, and Cancer(11), Diabetes and associated disorders(7), RNA modifications and cancer(3), Genetics and Neurodevelopmental Disorders(3)

Publications31 total

Author Correction: Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes
Nature Cell Biology·2025Open Access
m <sup>6</sup> A mRNA methylation decorates genes involved in fibrinogen synthesis to regulate liver regeneration in mice
American Journal of Physiology-Gastrointestinal and Liver Physiology·2025Open Access
&lt;b&gt;Regulatory roles of IGF2R in insulin secretion and adaptive β-cell proliferation&lt;/b&gt;
2025Open Access
Regulatory Roles of IGF2R in Insulin Secretion and Adaptive β-Cell Proliferation
Diabetes·2025· 2 cited
&lt;b&gt;Regulatory roles of IGF2R in insulin secretion and adaptive β-cell proliferation&lt;/b&gt;
2025Open Access
1557-P: Increased PAHSA Hydrolysis Driven by Mutant Carboxyl Ester Lipase (CEL) Contributes to Beta-Cell Dysfunction in MODY8
Diabetes·2024
Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes
Nature Cell Biology·2024· 44 citedOpen Access
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
Cell Metabolism·2023· 20 citedOpen Access
Redox Regulation of m <sup>6</sup> A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes
2023· 3 citedOpen Access
E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance
Cell Reports·2022· 24 citedOpen Access
Single-nucleus RNA-Seq reveals singular gene signatures of human ductal cells during adaptation to insulin resistance
JCI Insight·2022· 11 citedOpen Access
Emerging diabetes therapies: Bringing back the β-cells
Molecular Metabolism·2022· 44 citedOpen Access
Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8
Nature Metabolism·2022· 55 citedOpen Access
Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
Genome Medicine·2021· 40 citedOpen Access
Additional file 5 of Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
Figshare·2021Open Access
Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice
Journal of Clinical Investigation·2020· 81 citedOpen Access
Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway
Diabetologia·2020· 30 citedOpen Access
How, When, and Where Do Human β-Cells Regenerate?
Current Diabetes Reports·2019· 38 citedOpen Access
111-OR: Pancreatic Elastase Regulates Human Beta-Cell Proliferation via the Focal Adhesion and PAR2 Signaling Pathways
Diabetes·2019
Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes
Nature Metabolism·2019· 49 cited
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Frequent Co-authors

Rohit Kulkarni(17), Dario F. De Jesus(13), Sevim Kahraman(10), Ercument Dirice(8), Jiang Hu(8), Jun Shirakawa(6), Yasuo Terauchi(5), Sabrina Prudente(4), Vincenzo Trischitta(4), Natalie K. Brown(4), Rohit Kulkarni(4), Abdelfattah El Ouaamari(4), Weijun Qian(4), Amedeo Vetere(4), Bridget K. Wagner(4), Takahiro Tsuno(4), Diego Bailetti(3), Zijie Zhang(3), Ling Xiao(3), Jiang Hu(3)