Yiannis A. Ioannou

Icahn School of Medicine at Mount Sinai — United States

Medicine · Health Sciences

36h-index6.5kcitations73works0.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Lysosomal Storage Disorders Research(44), Cellular transport and secretion(18), Carbohydrate Chemistry and Synthesis(15), Cholesterol and Lipid Metabolism(12), Calcium signaling and nucleotide metabolism(9)

Publications73 total

Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction
iScience·2022· 8 citedOpen Access
Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer
Cancer Research·2018· 81 citedOpen Access
Functional variants in the <i>LRRK2</i> gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease
Science Translational Medicine·2018· 398 citedOpen Access
Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth
Journal of Clinical Investigation·2017· 196 citedOpen Access
Normalization of Hepatic Homeostasis in the Npc1 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat
Journal of Biological Chemistry·2016· 32 citedOpen Access
Abstract 3865: Therapeutic activation of protein phosphatase 2A for the treatment of lung cancer
Cancer Research·2016
Abstract B124: Drugging the undruggable: development of small molecule activators of protein phosphatase 2A for cancer treatment
Molecular Cancer Therapeutics·2015
Abstract 5329: Development of small molecule activators of protein phosphatase 2A for the treatment of lung cancer
Cancer Research·2015
Abstract A38: Therapeutic targeting of oncogenic KRAS signaling using a novel small molecule agonist of the PP2A tumor suppressor gene
Molecular Cancer Research·2014
PKC Activation in Niemann Pick C1 Cells Restores Subcellular Cholesterol Transport
PLoS ONE·2013· 21 citedOpen Access
MLN64 Transport to the Late Endosome Is Regulated by Binding to 14-3-3 via a Non-canonical Binding Site
PLoS ONE·2012· 29 citedOpen Access
An “Exacerbate-reverse” Strategy in Yeast Identifies Histone Deacetylase Inhibition as a Correction for Cholesterol and Sphingolipid Transport Defects in Human Niemann-Pick Type C Disease
Journal of Biological Chemistry·2011· 89 citedOpen Access
In vivo clearance and metabolism of recombinant activated factor VII (rFVIIa) and its complexes with plasma protease inhibitors in the liver
Thrombosis Research·2011· 16 cited
Cyclodextrin Induces Calcium-Dependent Lysosomal Exocytosis
PLoS ONE·2010· 113 citedOpen Access
Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent
Journal of Lipid Research·2009· 36 citedOpen Access
Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8
Journal of Lipid Research·2008· 60 citedOpen Access
Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and<i>Npc1l1</i><sup>−/−</sup>mice
American Journal of Physiology-Gastrointestinal and Liver Physiology·2008· 113 citedOpen Access
Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment
Biology of the Cell·2008· 57 cited
Niemann-Pick C1-Like 1 Is Required for an LXR Agonist to Raise Plasma HDL Cholesterol in Mice
Arteriosclerosis Thrombosis and Vascular Biology·2008· 51 citedOpen Access
Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids·2007· 59 cited
page 1 of 4Next →

Frequent Co-authors

Joanna P. Davies(20), Robert J. Desnick(10), Fannie W. Chen(9), Maureen E. Higgins(4), Kousaku Ohno(4), Weiqing Tang(4), Yinyan Ma(4), Liqing Yu(4), Ken M. Zeidner(4), Stephen L. Sturley(3), Marie T. Vanier(3), Catherine Scott(3), Yuko Sugimoto(3), Haruaki Ninomiya(3), Yuki Ohsaki(3), Katsumi Higaki(3), Ryan E. Temel(2), Lawrence L. Rudel(2), Anastasia Liapis(2), Ronald E. Gordon(2)