Heather Booth

Alnylam Pharmaceuticals (United States) — United States

Medicine · Health Sciences

17h-index2.0kcitations21works0.02yr avg
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Research Topics

Parkinson's Disease Mechanisms and Treatments(7), Nuclear Receptors and Signaling(7), Pluripotent Stem Cells Research(4), Nicotinic Acetylcholine Receptors Study(4), Neuroscience and Neuropharmacology Research(3)

Publications21 total

Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension
Neurology·2020· 75 citedOpen Access
RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes
Neurobiology of Disease·2019· 79 citedOpen Access
An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2
Neurobiology of Disease·2019· 72 citedOpen Access
Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons
Human Molecular Genetics·2019· 162 citedOpen Access
An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2
Oxford University Research Archive (ORA) (University of Oxford)·2019Open Access
MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons
Stem Cell Reports·2017· 56 citedOpen Access
The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis
Trends in Neurosciences·2017· 631 citedOpen Access
Modelling and analysis of LRRK2 mutations in iPSC-derived dopaminergic neurons and astrocytes
2017· 1 citedOpen Access
Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson’s disease
Human Molecular Genetics·2016· 74 citedOpen Access
Directing Differentiation of Pluripotent Stem Cells Toward Retinal Pigment Epithelium Lineage
Stem Cells Translational Medicine·2016· 49 citedOpen Access
ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
Stem Cell Reports·2016· 350 citedOpen Access
Direct Action Organizing:
Vanderbilt University Press eBooks·2015· 3 cited
Deletion of the nuclear receptor Nr2e1 impairs synaptic plasticity and dendritic structure in the mouse dentate gyrus
Neuroscience·2005· 32 cited
Structure-activity relationships for nicotine analogs comparing competition for [3H]nicotine binding and psychotropic potency
Drug Development Research·1998· 33 cited
Cognitive Performance and Regional Brain Volume in Human Immunodeficiency Virus Type 1 Infection
Archives of Neurology·1996· 74 cited
Temporal lobe atrophy in patients with Alzheimer disease: a CT study.
PubMed·1989· 57 citedOpen Access
Growth and Structure of Human Population in the Presence of Migration.
Population Studies·1984· 17 cited
Sites and mechanisms for nicotine's action in the brain
Neuroscience & Biobehavioral Reviews·1981· 96 cited
Chemical requirements of vasopressins for barrel rotation convulsions and reversal by oxytocin
Journal of Neuroscience Research·1980· 43 cited
Acute and chronic effects of nicotine in rats and evidence for a noncholinergic site of action.
PubMed·1979· 9 cited
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Frequent Co-authors

Richard Wade‐Martins(8), Jane Vowles(7), Sally A. Cowley(7), Leo G. Abood(4), Warren D. Hirst(3), Charmaine Lang(3), Joshua Shulman(3), Caleb Webber(3), Natalie Connor‐Robson(3), Cathy Browne(3), Hugo J. R. Fernandes(2), Brent J. Ryan(2), Samuel Evetts(2), Federico Zambon(2), Rory Bowden(2), Alexandre Guerreiro(2), Eric D. Caine(2), Jeffrey G. Martin(2), Benbo Gao(2), Kejie Li(2)