Walter M.A. Westerink

Charles River Laboratories (Netherlands) — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index1.4kcitations24works8.02yr avg
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Research Topics

Carcinogens and Genotoxicity Assessment(11), Pharmacogenetics and Drug Metabolism(7), Animal testing and alternatives(6), Effects and risks of endocrine disrupting chemicals(4), Contact Dermatitis and Allergies(4)

Publications24 total

HESI GTTC ring trial: Concordance between Ames and rodent carcinogenicity outcomes for N-nitrosamines (NAs) with rat and hamster metabolic conditions
Regulatory Toxicology and Pharmacology·2025· 6 citedOpen Access
Human relevance of in vivo and in vitro skin irritation tests for hazard classification of pesticides
Cutaneous and Ocular Toxicology·2024· 10 citedOpen Access
Assessment of the utility of the novel Phenion® full thickness human skin model for detecting the skin irritation potential of antimicrobial cleaning products
Toxicology in Vitro·2023· 7 citedOpen Access
Assessment of the skin sensitization potential of fragrance ingredients using the U-SENS™ assay
Toxicology in Vitro·2021· 5 citedOpen Access
REACH alternative testing strategy for skin sensitization in practice: Fact or fiction?
Regulatory Toxicology and Pharmacology·2019· 5 cited
Non in vivo skin sensitization strategy under REACh in practice: Hurdles that need attention to minimize the need for in vivo testing
Toxicology Letters·2018
Safety evaluation of rebaudioside A produced by fermentation
Food and Chemical Toxicology·2016· 14 cited
High‐Throughput Toxicity Testing in Drug Development: Aims, Strategies, and Novel Trends
2013· 2 cited
Genotoxicity and Carcinogenicity: Regulatory and Novel Test Methods
2013· 2 cited
Robust Array-Based Coregulator Binding Assay Predicting ERα-Agonist Potency and Generating Binding Profiles Reflecting Ligand Structure
Chemical Research in Toxicology·2013· 32 citedOpen Access
Cytotoxic effects of 109 reference compounds on rat H4IIE and human HepG2 hepatocytes. III: Mechanistic assays on oxygen consumption with MitoXpress and NAD(P)H production with Alamar Blue™
Toxicology in Vitro·2012· 26 cited
Development and validation of a high-content screening in vitro micronucleus assay in CHO-k1 and HepG2 cells
Mutation Research/Genetic Toxicology and Environmental Mutagenesis·2011· 67 cited
The development of improved and new in vitro assays for detecting the genotoxic and non-genotoxic carcinogenic potential of chemicals in the discovery phase of drug development
2011Open Access
The development of RAD51C, Cystatin A, p53 and Nrf2 luciferase-reporter assays in metabolically competent HepG2 cells for the assessment of mechanism-based genotoxicity and of oxidative stress in the early research phase of drug development
Mutation Research/Genetic Toxicology and Environmental Mutagenesis·2009· 73 cited
RAD51C, Cystatin A, p53, Nrf2 luciferase-based reporter assays in metabolic competent HepG2 cells for the rapid assessment of genotoxicity, oxidative stress in the early research phase
Toxicology Letters·2009
Evaluation of the Vitotox™ and RadarScreen assays for the rapid assessment of genotoxicity in the early research phase of drug development
Mutation Research/Genetic Toxicology and Environmental Mutagenesis·2009· 74 cited
High-throughput screening for analysis of in vitro toxicity
Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions·2009· 63 cited
Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition
Archives of Toxicology·2008· 41 cited
CYP1A induction and species differences between human HepG2 and rat H4IIE cells
Toxicology Letters·2007· 2 cited
Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells
Toxicology in Vitro·2007· 213 cited
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Frequent Co-authors

W.G.E.J. Schoonen(15), Joe C.R. Stevenson(7), G. Jean Horbach(6), Jeroen A.D.M. de Roos(3), Eric Débiton(3), Kathryn Page(2), Kristie Sullivan(2), Helma M. Barentsen(2), Simon U. Jonis(2), S.M.G.J. Pelgrom(2), Jeroen C.W. Rijk(2), Jeannette J.C. Paulussen(2), Femke M. van de Water(2), Annick Lauwers(1), Gerard Griffioen(1), Tom J.J. Schirris(1), J.M.M.J.G. Aarts(1), Si Wang(1), René Houtman(1), Rinie M. G. J. van Beuningen(1)