W.G.E.J. Schoonen

National Institute for Public Health and the Environment — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

36h-index4.3kcitations92works0.02yr avg
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Research Topics

Estrogen and related hormone effects(24), Reproductive biology and impacts on aquatic species(18), Carcinogens and Genotoxicity Assessment(14), Computational Drug Discovery Methods(13), Hormonal and reproductive studies(13)

Publications92 total

The effects of aliphatic alcohols and related acid metabolites in zebrafish embryos - correlations with rat developmental toxicity and with effects in advanced life stages in fish
Toxicology and Applied Pharmacology·2020· 5 cited
Distinguishing mode of action of compounds inducing craniofacial malformations in zebrafish embryos to support dose-response modeling in combined exposures
Reproductive Toxicology·2020· 14 citedOpen Access
Application of the comparison approach to open TG-GATEs: A useful toxicogenomics tool for detecting modes of action in chemical risk assessment
Food and Chemical Toxicology·2018· 21 cited
Effects of Capillary Microsampling on Toxicological Endpoints in Juvenile Rats
Toxicological Sciences·2016· 14 citedOpen Access
Acute toxicity of CCl4 but not of paracetamol induces a transcriptomic signature of fibrosis in precision-cut liver slices
Toxicology in Vitro·2015· 24 citedOpen Access
High‐Throughput Toxicity Testing in Drug Development: Aims, Strategies, and Novel Trends
2013· 2 cited
Genotoxicity and Carcinogenicity: Regulatory and Novel Test Methods
2013· 2 cited
Cellular‐signaling pathways unveil the carcinogenic potential of chemicals
Journal of Applied Toxicology·2013· 19 citedOpen Access
Cellular-signaling pathways unveil the carcinogenic potential of chemicals
Data Archiving and Networked Services (DANS)·2013
Org 214007-0: A Novel Non-Steroidal Selective Glucocorticoid Receptor Modulator with Full Anti-Inflammatory Properties and Improved Therapeutic Index
PLoS ONE·2012· 35 citedOpen Access
Canid Progesterone Receptors Lack Activation Function 3 Domain-Dependent Activity
Endocrinology·2012· 7 citedOpen Access
Cytotoxic effects of 109 reference compounds on rat H4IIE and human HepG2 hepatocytes. III: Mechanistic assays on oxygen consumption with MitoXpress and NAD(P)H production with Alamar Blue™
Toxicology in Vitro·2012· 26 cited
Identification of Different Mechanisms of Non-Genotoxic Carcinogens Based on Gene Expression Profiling in Primary Mouse Hepatocytes
Data Archiving and Networked Services (DANS)·2011
High content screening analysis of phospholipidosis: Validation of a 96-well assay with CHO-K1 and HepG2 cells for the prediction of in vivo based phospholipidosis
Toxicology in Vitro·2011· 39 cited
Development and validation of a high-content screening in vitro micronucleus assay in CHO-k1 and HepG2 cells
Mutation Research/Genetic Toxicology and Environmental Mutagenesis·2011· 67 cited
Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes
Toxicology and Applied Pharmacology·2011· 63 cited
Gene expression analysis of precision-cut human liver slices indicate stable expression of hepatotoxicity related genes
University of Groningen research database (University of Groningen / Centre for Information Technology)·2011
A comparative integrated transcript analysis and functional characterization of differential mechanisms for induction of liver hypertrophy in the rat
Toxicology and Applied Pharmacology·2011· 27 cited
Validation of in vitro screening models for progestagenic activities: Inter-assay comparison and correlation with in vivo activity in rabbits
Toxicology in Vitro·2010· 51 cited
Gene expression analysis of precision cut human liver slices indicate stable expression of ADME-Tox related genes
Toxicology Letters·2010· 1 cited
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Frequent Co-authors

Walter M.A. Westerink(10), J.G.D. Lambert(8), G. Jean Horbach(7), P. G. W. J. van Oordt(6), H.J. Kloosterboer(5), G.H. Deckers(5), R. van den Hurk(4), Joe C.R. Stevenson(4), J.W. Resink(4), H.J. Kloosterboer(3), J.G.D. Lambert(3), R. Dijkema(3), Willem Viveen(3), Edwin Sonneveld(2), Bart Pieterse(2), Jeroen A.D.M. de Roos(2), Eric Débiton(2), Marcel E. de Gooyer(2), Hans Joenje(2), Peter Olinga(2)