Marcel E. de Gooyer

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index629citations17works0.02yr avg
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Research Topics

Estrogen and related hormone effects(11), Ophthalmology and Eye Disorders(4), Steroid Chemistry and Biochemistry(4), Endometriosis Research and Treatment(3), Reproductive System and Pregnancy(3)

Publications17 total

Complete Inhibition of rhTSH-, Graves' Disease IgG-, and M22-Induced cAMP Production in Differentiated Orbital Fibroblasts by a Low-Molecular-Weight TSHR Antagonist
The Journal of Clinical Endocrinology & Metabolism·2012· 39 citedOpen Access
Mechanism of action of a nanomolar potent, allosteric antagonist of the thyroid‐stimulating hormone receptor
British Journal of Pharmacology·2011· 46 citedOpen Access
Thyrotropin Receptor-Stimulating Graves' Disease Immunoglobulins Induce Hyaluronan Synthesis by Differentiated Orbital Fibroblasts from Patients with Graves' Ophthalmopathy Not Only Via Cyclic Adenosine Monophosphate Signaling Pathways
Thyroid·2010· 51 cited
Effects of Thyrotropin and Thyrotropin-Receptor-Stimulating Graves' Disease Immunoglobulin G on Cyclic Adenosine Monophosphate and Hyaluronan Production in Nondifferentiated Orbital Fibroblasts of Graves' Ophthalmopathy Patients
Thyroid·2010· 33 cited
Fadrozole Reverses Cardiac Fibrosis in Spontaneously Hypertensive Heart Failure Rats: Discordant Enantioselectivity Versus Reduction of Plasma Aldosterone
Endocrinology·2007· 23 citedOpen Access
Metabolism of tibolone and its metabolites in uterine and vaginal tissue of rat and human origin
The Journal of Steroid Biochemistry and Molecular Biology·2006· 6 cited
Tibolone and metabolites induce prolactin production in human endometrial stromal cells in vitro: Evidence for cell-specific metabolism
The Journal of Steroid Biochemistry and Molecular Biology·2006· 4 cited
Molecular Portrait of the Progestagenic and Estrogenic Actions of Tibolone: Behavior of Cellular Networks in Response to Tibolone
The Journal of Clinical Endocrinology & Metabolism·2005· 25 citedOpen Access
Progestagenic Effects of Tibolone on Human Endometrial Cancer Cells
The Journal of Clinical Endocrinology & Metabolism·2003· 35 citedOpen Access
Tibolone is not converted by human aromatase to 7α-methyl-17α-ethynylestradiol (7α-MEE):
Steroids·2003· 59 cited
Receptor profiling and endocrine interactions of tibolone
Steroids·2002· 127 cited
Tibolone and 5α-dihydrotestosterone alone or in combination with an antiandrogen in a rat breast tumour model
European Journal of Cancer·2002· 9 cited
(Q) SAR study on the metabolic stability of steroidal androgens
Journal of Molecular Graphics and Modelling·2001· 18 cited
Tibolone: a compound with tissue specific inhibitory effects on sulfatase
Molecular and Cellular Endocrinology·2001· 89 cited
Sulphatase inhibition by tibolone prevents stimulation of breast and endometrium
International Journal of Gynecology & Obstetrics·2000
Human progesterone receptor A and B isoforms in CHO cells. II. Comparison of binding, transactivation and ed50 values of several synthetic (anti)progestagens in vitro in CHO and MCF-7 cells and in vivo in rabbits and rats
The Journal of Steroid Biochemistry and Molecular Biology·1998· 41 cited
Pharmacological Properties of a New Selective Antiprogestagen: Org 33628
Annals of the New York Academy of Sciences·1995· 24 cited

Frequent Co-authors

H.J. Kloosterboer(5), G.H. Deckers(4), H.A.M. Verheul(4), Chris J. van Koppen(4), André M. M. Miltenburg(4), W.G.E.J. Schoonen(3), Helenius J. Kloosterboer(3), A. Ederveen(3), Clementine J.J. van Zeijl(3), Eric Fliers(3), Olga V. Surovtseva(3), Wilmar M. Wiersinga(3), Anita Boelen(3), Ralf Plate(3), H.J. Kloosterboer(3), Dirk Leysen(2), Maarten P. Mourits(2), Willem-Jan F. Karstens(2), Paolo Conti(2), R. Dijkema(2)