Humbert De Smedt

KU Leuven — Belgium

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index1.8kcitations27works0.02yr avg
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Research Topics

Genetic and Kidney Cyst Diseases(9), Biomedical Research and Pathophysiology(7), Ion channel regulation and function(5), Autophagy in Disease and Therapy(5), Hedgehog Signaling Pathway Studies(4)

Publications27 total

PKD2/polycystin-2 induces autophagy by forming a complex with BECN1
Autophagy·2020· 37 citedOpen Access
Fundamental insights into autosomal dominant polycystic kidney disease from human-based cell models
Pediatric Nephrology·2018· 7 citedOpen Access
Polycystin-2-dependent control of cardiomyocyte autophagy
Journal of Molecular and Cellular Cardiology·2018· 40 citedOpen Access
Everolimus halts hepatic cystogenesis in a rodent model of polycystic-liver-disease
World Journal of Gastroenterology·2017· 12 citedOpen Access
Autophagy in renal diseases
Pediatric Nephrology·2015· 78 citedOpen Access
Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin
Pflügers Archiv - European Journal of Physiology·2013· 30 cited
Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis
Cell Calcium·2013· 31 citedOpen Access
mTOR-Controlled Autophagy Requires Intracellular Ca2+ Signaling
PLoS ONE·2013· 115 citedOpen Access
Polycystins and cellular Ca2+ signaling
Cellular and Molecular Life Sciences·2012· 36 citedOpen Access
Polycystin-1 and polycystin-2 are both required to amplify inositol-trisphosphate-induced Ca2+ release
Cell Calcium·2012· 51 cited
F508del-CFTR increases intracellular Ca2+ signaling that causes enhanced calcium-dependent Cl− conductance in cystic fibrosis
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease·2011· 38 citedOpen Access
Endoplasmic-Reticulum Calcium Depletion and Disease
Cold Spring Harbor Perspectives in Biology·2011· 473 citedOpen Access
1 F508del-CFTR increases intracellular Ca 2+ signaling that causes enhanced 2 calcium-dependent Clconductance in cystic fibrosis☆
2011
Unraveling the role of polycystin-2/inositol 1,4,5-trisphosphate receptor interaction in Ca<sup>2+</sup> signaling
Communicative & Integrative Biology·2010· 11 citedOpen Access
Polycystin-2 Activation by Inositol 1,4,5-Trisphosphate-induced Ca2+ Release Requires Its Direct Association with the Inositol 1,4,5-Trisphosphate Receptor in a Signaling Microdomain
Journal of Biological Chemistry·2010· 126 citedOpen Access
Differential contribution of the Na <sup>+</sup> ‐K <sup>+</sup> ‐2Cl <sup>−</sup> cotransporter NKCC1 to chloride handling in rat embryonic dorsal root ganglion neurons and motor neurons
The FASEB Journal·2008· 26 citedOpen Access
The IRBIT domain adds new functions to the AHCY family
BioEssays·2008· 43 citedOpen Access
TRPM8-independent Menthol-induced Ca2+ Release from Endoplasmic Reticulum and Golgi
Journal of Biological Chemistry·2006· 133 citedOpen Access
The Ca2+/Mn2+ pumps in the Golgi apparatus
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2004· 129 cited
SPCA1 pumps and Hailey–Hailey disease
Biochemical and Biophysical Research Communications·2004· 101 cited
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Frequent Co-authors

Jan B. Parys(11), Ludwig Missiaen(11), Djalila Mekahli(8), Geert Bultynck(8), Eva Sammels(7), Jean-Paul Decuypere(4), Kirsten Welkenhuyzen(4), Jo Vanoevelen(3), Geert Callewaert(3), Luc Raeymaekers(3), Frank Wuytack(3), Benoit Devogelaere(3), Tomas Luyten(3), R. Casteels(3), Lambertus P. van den Heuvel(3), Elena Levtchenko(3), Leen Verbert(2), Bernd Nilius(2), Kurt Van Baelen(2), Leonard Dode(2)