Jan B. Parys

Centre Hospitalier Universitaire Brugmann — Belgium

Biochemistry, Genetics and Molecular Biology · Life Sciences

75h-index31.5kcitations333works2.72yr avg
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Research Topics

Ion channel regulation and function(88), Protein Kinase Regulation and GTPase Signaling(79), Calcium signaling and nucleotide metabolism(69), Cell death mechanisms and regulation(46), Cellular transport and secretion(44)

Publications329 total

CISD2 ensures adequate ER-mitochondrial coupling, critically supporting mitochondrial function in neurons
Acta Neuropathologica Communications·2025Open Access
Prevalence, awareness and therapeutic control of hypertension in Belgium: an opportunistic screening of nearly 6,000 participants during the May Measurement Month campaigns 2017–23
Blood Pressure·2025· 5 citedOpen Access
Cisd2 ensures adequate ER-mitochondrial coupling, thereby critically supporting mitochondrial function in neurons
2025Open Access
The IP3 receptor-KRAP complex at the desmosomes: A new player in the apoptotic process
Cell Calcium·2024
CISD2 counteracts the inhibition of ER-mitochondrial calcium transfer by anti-apoptotic BCL-2
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2024· 9 citedOpen Access
Tetrameric, active PKM2 inhibits IP3 receptors, potentially requiring GRP75 as an additional interaction partner
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2024· 2 citedOpen Access
The interplay between associated proteins, redox state and Ca2+ in the intraluminal ER compartment regulates the IP3 receptor
Cell Calcium·2023· 6 citedOpen Access
The Complex Effects of PKM2 and PKM2:IP3R Disruption on Intracellular Ca2+ Handling and Cellular Functions
Cells·2023· 2 citedOpen Access
Modalities of cell death, survival and adaptation: The role of the Ca2+-signaling toolkit
Cell Calcium·2023· 3 citedOpen Access
LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner
Cell Death and Disease·2023· 19 citedOpen Access
The ER-mitochondria interface, where Ca2+ and cell death meet
Cell Calcium·2023· 61 citedOpen Access
Sec61 complex/translocon: The role of an atypical ER Ca2+-leak channel in health and disease
Frontiers in Physiology·2022· 15 citedOpen Access
Modulation of Ca2+ signaling by antiapoptotic Bcl-2 versus Bcl-xL: From molecular mechanisms to relevance for cancer cell survival
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer·2022· 35 citedOpen Access
TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy
Life Science Alliance·2022· 31 citedOpen Access
Rhomboid pseudoproteases: An Achilles heel's for BCL-2/IP3R-dependent resistance to ER stress-induced cell death
Cell Calcium·2022· 1 citedOpen Access
TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescence
Nature Communications·2022· 75 citedOpen Access
A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca2+ signalling through IP3 receptors
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2022· 12 citedOpen Access
Preface to the Special Issue of the European Calcium Society in honor of Professor Sir Michael J. Berridge
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2021Open Access
Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis
Cell Death and Differentiation·2021· 79 citedOpen Access
Uniting the divergent Wolfram syndrome–linked proteins WFS1 and CISD2 as modulators of Ca<sup>2+</sup>signaling
Science Signaling·2021· 32 citedOpen Access
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Frequent Co-authors

Geert Bultynck(30), Humbert De Smedt(29), Ludwig Missiaen(26), Martin D. Bootman(10), R. Casteels(6), Jean-Paul Decuypere(6), Giovanni Monaco(6), Clark Distelhorst(5), Geert Callewaert(5), Tim Vervliet(5), Humbert De Smedt(4), H. Llewelyn Roderick(4), Mart Bittremieux(4), Ilse Sienaert(4), Yi-Ping Rong(3), Fei Zhong(3), Katja Rietdorf(3), Tomas Luyten(3), Nael Nadif Kasri(3), Michael J. Berridge(3)