Patrick G. Needham

Miami University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index1.5kcitations30works3.52yr avg
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Research Topics

Endoplasmic Reticulum Stress and Disease(8), Heat shock proteins research(7), Bacterial Genetics and Biotechnology(3), Fungal and yeast genetics research(3), Autophagy in Disease and Therapy(3)

Publications30 total

IbpAB small heat shock proteins are not host factors for bacteriophage ϕX174 replication
Virology·2024· 1 citedOpen Access
Phage-layer interferometry: a companion diagnostic for phage therapy and a bacterial testing platform
Scientific Reports·2024· 6 citedOpen Access
Differential regulation of <scp>MAP2</scp> by phosphorylation events in proline‐rich versus C‐terminal domains
The FASEB Journal·2023· 6 citedOpen Access
SLC26A9 is selected for endoplasmic reticulum associated degradation (ERAD) via Hsp70-dependent targeting of the soluble STAS domain
Biochemical Journal·2021· 6 citedOpen Access
Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy
Neurotherapeutics·2021· 10 citedOpen Access
A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation
Science·2019· 156 citedOpen Access
RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43
Neuron·2019· 548 citedOpen Access
Chaperoning Endoplasmic Reticulum–Associated Degradation (ERAD) and Protein Conformational Diseases
Cold Spring Harbor Perspectives in Biology·2019· 142 citedOpen Access
Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding
Bioorganic & Medicinal Chemistry·2018· 21 cited
Pulsed Plasma Thruster for Multi-Axis CubeSat Attitude Control Applications
2018 Joint Propulsion Conference·2018· 2 cited
Select α-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model
Journal of Biological Chemistry·2018· 20 citedOpen Access
Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase
Scientific Reports·2017· 28 citedOpen Access
Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members
Bioorganic & Medicinal Chemistry Letters·2016· 24 citedOpen Access
Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions
Journal of Molecular Biology·2015· 19 citedOpen Access
Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast<i>Saccharomyces cerevisiae</i>
Physiological Genomics·2015· 10 citedOpen Access
Loss of Ypk1, the Yeast Homolog to the Human Serum- and Glucocorticoid-induced Protein Kinase, Accelerates Phospholipase B1-mediated Phosphatidylcholine Deacylation
Journal of Biological Chemistry·2014· 15 citedOpen Access
ESCRT regulates surface expression of the Kir2.1 potassium channel
Molecular Biology of the Cell·2013· 31 cited
How early studies on secreted and membrane protein quality control gave rise to the ER associated degradation (ERAD) pathway: The early history of ERAD
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2013· 72 citedOpen Access
Cytoplasmic Hsp70 and Hsp90 regulate functionally distinct ER quality control checkpoints during thiazide‐sensitive NaCl cotransporter biogenesis
The FASEB Journal·2013
Hsp70 and Hsp90 Multichaperone Complexes Sequentially Regulate Thiazide-sensitive Cotransporter Endoplasmic Reticulum-associated Degradation and Biogenesis
Journal of Biological Chemistry·2013· 63 citedOpen Access
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Frequent Co-authors

Jeffrey L. Brodsky(19), Peter Wipf(4), Avin C. Snyder(3), Shaheen Khadem(3), Arohan R. Subramanya(3), James P. Trempe(3), Christopher J. Guerriero(2), P. Scott(2), B A Wharton(2), Annette Chiang(2), Bridget F. Donnelly(2), Ankita Roy(2), Kristin C. Verrill(2), Roy F. Collaco(2), Alexander Kolb(2), Carlos J. Camacho(2), Alexandra Manos‐Turvey(2), Jennifer L. Goeckeler-Fried(2), John David Dignam(2), Kevin Yehl(2)