Gregory J. Christianson

Jackson Laboratory — United States

Immunology and Microbiology · Life Sciences

37h-index4.5kcitations74works0.02yr avg
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Research Topics

T-cell and B-cell Immunology(36), Immune Cell Function and Interaction(31), Monoclonal and Polyclonal Antibodies Research(25), Immunotherapy and Immune Responses(20), Glycosylation and Glycoproteins Research(11)

Publications74 total

An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics
Science Translational Medicine·2020· 65 citedOpen Access
Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human <i>FCGRT</i> transgenic mice
mAbs·2020· 15 citedOpen Access
Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex–mediated immune responses
Science Advances·2019· 119 citedOpen Access
Characterization and Optimization of SLE Mouse Models for the Evaluation of Immunomodulation Therapeutics
The Journal of Immunology·2019
Abstract 4905: Utility of human FcRn transgenic mice for preclinical screening of immunotherapeutics
Cancer Research·2018
Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice
mAbs·2018· 35 citedOpen Access
Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development
Diabetes·2018· 23 citedOpen Access
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules
Nature Communications·2018· 85 citedOpen Access
Precocious Interleukin 21 Expression in Naive Mice Identifies a Natural Helper Cell Population in Autoimmune Disease
Cell Reports·2017· 21 citedOpen Access
Albumin, in the Presence of Calcium, Elicits a Massive Increase in Extracellular Bordetella Adenylate Cyclase Toxin
Infection and Immunity·2017· 26 citedOpen Access
Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury
Proceedings of the National Academy of Sciences·2017· 103 citedOpen Access
Interleukin 6 Accelerates Mortality by Promoting the Progression of the Systemic Lupus Erythematosus-Like Disease of BXSB.Yaa Mice
PLoS ONE·2016· 31 citedOpen Access
Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies
Methods in molecular biology·2016· 28 cited
Interleukin 6 (IL6) is an important upstream contributor towards the progression of SLE-like disease in BXSB.Yaa mice (BA11P.134)
The Journal of Immunology·2015
An IL21 reporter mouse reveals a novel population of TFH precursors in young mice. (LYM8P.630)
The Journal of Immunology·2015
Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs
mAbs·2015· 81 citedOpen Access
A novel population of interleukin 21-producing pre-follicular T helper cells develop spontaneously in young naïve mice (LYM3P.743)
The Journal of Immunology·2014
Intricate interplay of cytokines determine the progression of SLE-like disease in BXSB.Yaa mice (BA12P.104)
The Journal of Immunology·2014
Dissection of the Neonatal Fc Receptor (FcRn)-Albumin Interface Using Mutagenesis and Anti-FcRn Albumin-blocking Antibodies
Journal of Biological Chemistry·2014· 44 citedOpen Access
Expression of Neonatal Fc Receptor in the Eye
Investigative Ophthalmology & Visual Science·2014· 59 citedOpen Access
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Frequent Co-authors

Derry C. Roopenian(44), Thomas J. Sproule(12), David Serreze(7), Nilabh Shastri(6), Sebastian Joyce(6), Shreeram Akilesh(5), Jan Terje Andersen(5), Yoshitaka Yoshimura(5), Eun Young Choi(4), Peter Eden(4), Edward H. Leiter(4), Subramaniam Malarkannan(4), Inger Sandlie(4), Gabriele Proetzel(4), Nadja Jung(3), Stefka B. Petkova(3), Aamir Zuberi(3), Teresa P. DiLorenzo(3), Stanley G. Nathenson(3), Richard S. Blumberg(3)