K. Conners

Medicine · Health Sciences

8h-index1.2kcitations21works5.02yr avg
OpenAlex↗Google Scholar↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Cystic Fibrosis Research Advances(8), Neonatal Respiratory Health Research(7), Receptor Mechanisms and Signaling(4), Inhalation and Respiratory Drug Delivery(3), Immune Response and Inflammation(2)

Publications21 total

Computational design of highly signalling-active membrane receptors through solvent-mediated allosteric networks
Nature Chemistry·2025· 5 citedOpen Access
Computational design of highly signaling active membrane receptors through de novo solvent-mediated allosteric networks
2023Open Access
Computational design of highly signaling active membrane receptors through <i>de novo</i> solvent-mediated allosteric networks
2021Open Access
Structural basis for GPR40 allosteric agonism and incretin stimulation
Nature Communications·2018· 85 citedOpen Access
Discovery of (1<i>S</i>,2<i>R</i>,3<i>S</i>,4<i>S</i>,5<i>R</i>,6<i>R</i>)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity
Journal of Medicinal Chemistry·2016· 29 citedOpen Access
Metabotropic Glutamate Receptor in complex with antagonist (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
2016
Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant
Protein Engineering Design and Selection·2010· 98 cited
Structure and Dynamics of NBD1 from CFTR Characterized Using Crystallography and Hydrogen/Deuterium Exchange Mass Spectrometry
Journal of Molecular Biology·2009· 127 cited
Crystal structure of human NBD2 complexed with N6-Phenylethyl-ATP (P-ATP)
2009· 3 cited
Minimal human CFTR first nucleotide binding domain as a monomer
2007
Minimal human CFTR first nucleotide binding domain as a head-to-tail dimer with delta F508
2007
Minimal human CFTR first nucleotide binding domain as a head-to-tail dimer
2007
Human deltaF508 NBD1 with three solubilizing mutations
2005
Impact of the ΔF508 Mutation in First Nucleotide-binding Domain of Human Cystic Fibrosis Transmembrane Conductance Regulator on Domain Folding and Structure
Journal of Biological Chemistry·2004· 272 citedOpen Access
Crystal structure of human deltaF508 human NBD1 domain with ATP
2004
Structure of nucleotide‐binding domain 1 of the cystic fibrosis transmembrane conductance regulator
The EMBO Journal·2003· 406 citedOpen Access
Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) apo
2003
Phosphorylated Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) with ATP
2003
mouse CFTR NBD1 with AMP.PNP
2003
Myeloid Development Is Selectively Disrupted in PU.1 Null Mice
Blood·1998· 191 cited
page 1 of 2Next →

Frequent Co-authors

H.A. Lewis(12), J.M. Sauder(9), Spencer Emtage(9), S. Atwell(7), T. Gheyi(6), Bradley Condon(6), William B. Guggino(5), J.F. Hunt(5), M.C. Kearins(5), Logan Rodgers(5), S.R. Wasserman(5), Sean G. Buchanan(4), S.K. Burley(4), M. Dickey(4), Michael R. Dorwart(4), Wayne A. Hendrickson(4), Peter C. Maloney(4), Xun Zhao(4), Xiaoliang Zhao(4), Frances Lu(4)