Hanan S. Althagafy

University of Jeddah — Saudi Arabia

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index415citations45works3.62yr avg
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Research Topics

Genomics, phytochemicals, and oxidative stress(10), Chemotherapy-induced organ toxicity mitigation(10), Drug-Induced Hepatotoxicity and Protection(6), Heavy Metal Exposure and Toxicity(4), Inflammasome and immune disorders(4)

Publications45 total

The protective effect of ambroxol against cyclophosphamide-induced acute kidney injury involves Nrf2/HO-1 signaling upregulation and suppression of oxidative and inflammatory damage
Naunyn-Schmiedeberg s Archives of Pharmacology·2026
Reynoutrin Mitigates Metabolic, Immune, and Redox Dysregulation in Acute Dyslipidemia
Kafkas Universitesi Veteriner Fakultesi Dergisi·2026Open Access
Renoprotective effect of diosmin against chlorpyrifos-induced kidney injury is mediated by the regulation of TLR4/HMGB1/NF-κB, PPAR-γ/SIRT1, and Bax/Bcl2 signals
Journal of Molecular Histology·2025
Nifuroxazide attenuates bisphenol A–induced male reproductive toxicity by modulating oxidative stress, inflammation, and Nrf2/HO-1 and necroptosis pathways
Tissue and Cell·2025
Harnessing GSK-3β inhibition for lung cancer therapy: emerging opportunities and challenges
Medical Oncology·2025· 1 citedOpen Access
Protective role of S-carboxymethylcysteine against cyclophosphamide nephrotoxicity: involvement of Nrf2/HO-1 signaling and suppression of oxidative stress, inflammation, and apoptosis
Molecular & Cellular Toxicology·2025
Candesartan preserves aortic structure and function in cisplatin-treated rats by upregulating SIRT1/Nrf2/HO-1 signaling and suppressing oxidative stress, TLR-4/NF-κB signaling, and necroptosis
Frontiers in Pharmacology·2025Open Access
Umbelliferone reverses neuronal damage induced by chronic Chlorpyrifos exposure via suppressing NF-κB/STAT3/NLRP3 and boosting Keap-1/Nrf2/HO-1 signals
Metabolic Brain Disease·2025
S-Carboxymethylcysteine Mitigates Cyclophosphamide-Induced Hepatotoxicity by Modulating TLR-4/NF-κB Signaling and Redox Homeostasis
Bratislavské lekárske listy/Bratislava medical journal·2025Open Access
Ambroxol mitigates cyclophosphamide-induced liver injury by suppressing TLR-4/NF-κB signaling and oxidative stress and upregulating cytoglobin, TXNRD1 and HMGB1
World Journal of Gastroenterology·2025Open Access
Protective effect of ambroxol on cyclophosphamide-induced intestinal damage: involvement of oxidative stress, inflammation, and Keap-1/Nrf2/HO-1 signaling
Journal of Molecular Histology·2025
Attenuation of NF-κB/NLRP3 inflammasome axis and oxidative stress, and upregulation of Nrf2/HO-1 signaling mediate the protective effect of S-carboxymethylcysteine against cyclophosphamide-induced cardiotoxicity
Tissue and Cell·2025· 1 cited
Modulation of NF-κB/NLRP3 inflammasome axis, Nrf2/HO-1 signaling and attenuation of oxidative stress mediate the protective effect of ambroxol against cyclophosphamide cardiotoxicity
Biochemical and Biophysical Research Communications·2025· 3 cited
The role of Wnt/β-catenin signaling in lung cancer progression and therapy: a comprehensive review
Medical Oncology·2025· 2 cited
Flavonoids in Combating Renal Fibrosis: Targeting NF‐κB Signal and In Silico Support
Chemistry & Biodiversity·2025· 3 citedOpen Access
Morin Mitigates 5-Fluorouracil-Induced Nephrotoxicity by Activating Nrf2/HO-1 and FXR, and Suppressing ERK/VCAM-1 and NF-κB Pathways
International Immunopharmacology·2025· 4 cited
Vinpocetine attenuates 5-fluorouracil-induced intestinal injury: role of the Keap1/Nrf2/HO-1, NF-κB/TLR4/SOCS3 and RIPK1/RIPK3/MLKL signals
Immunopharmacology and Immunotoxicology·2024· 2 cited
Hepatoprotective effects of diosmin: a narrative review
Naunyn-Schmiedeberg s Archives of Pharmacology·2024· 9 citedOpen Access
Fluoxetine attenuates chlorpyrifos-induced neuronal injury through the PPARγ, SIRT1, NF-κB, and JAK1/STAT3 signals
International Immunopharmacology·2024· 2 cited
Quetiapine attenuates cadmium neurotoxicity by suppressing oxidative stress, inflammation, and pyroptosis
Molecular Biology Reports·2024· 5 cited
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Frequent Co-authors

Emad H. M. Hassanein(20), Emad H. M. Hassanein(17), Islam M. Ibrahim(12), Esraa K. Abd‐alhameed(9), Fares E.M. Ali(9), Reem S. Alruhaimi(9), Ayman M. Mahmoud(8), Sulaiman Mohammed Alnasser(7), Mostafa S. Abd El‐Maksoud(5), Steve Harakeh(5), Ahmad Ahmeda(5), Omnia A. M. Abd El‐Ghafar(5), Zeina W. Sharawi(4), Ahmed M. Atwa(4), Mohamed Baraka(4), Maram T. Basha(4), Ahlam I. Al‐Sulami(4), Khadijah M. Al‐Zaydi(4), Fatima A. Jaber(3), Mostafa K. Abd El‐Aziz(3)