Edgar Jacoby

Janssen (Belgium) — Belgium

Computer Science · Physical Sciences

34h-index5.3kcitations128works5.62yr avg
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Research Topics

Computational Drug Discovery Methods(61), Chemical Synthesis and Analysis(22), Protein Structure and Dynamics(20), Receptor Mechanisms and Signaling(18), Microbial Natural Products and Biosynthesis(15)

Publications128 total

Application of Semiempirical Quantum Mechanical Methods To Accurately Estimate Ligand-Binding Structure in Biological Systems: Protein Kinase Case Study
Journal of Chemical Information and Modeling·2026
A New Fragment‐Based Pharmacophore Virtual Screening Workflow Identifies Potent Inhibitors of <scp>SARS</scp> ‐ <scp>CoV</scp> ‐2 <scp>NSP13</scp> Helicase
Journal of Computational Chemistry·2025· 2 citedOpen Access
Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase
Journal of Virology·2025· 4 citedOpen Access
DNA-Encoded Library Screen Identifies Novel Series of Respiratory Syncytial Virus Polymerase Inhibitors
Journal of Medicinal Chemistry·2025· 3 cited
Targeting Druggable Pockets in Dengue Virus Envelope Protein: Insights from Structural Analysis and High-Throughput Screening
SSRN Electronic Journal·2025Open Access
P681: Molecular diagnosis of DMD-related dystrophinopathies in patients with non-representative phenotypes by using a broad neuromuscular next generation sequencing (NGS) panel
Genetics in Medicine Open·2025Open Access
Identification of isoquinolinone DHODH inhibitor isosteres
Bioorganic & Medicinal Chemistry Letters·2024
Discovery of <i>gem</i>-Dimethyl-hydroxymethylpyridine Derivatives as Potent Non-nucleoside RSV Polymerase Inhibitors
Journal of Medicinal Chemistry·2024· 8 cited
Structure–Activity Relationship of Oxacyclo- and Triazolo-Containing Respiratory Syncytial Virus Polymerase Inhibitors
ACS Medicinal Chemistry Letters·2024· 3 citedOpen Access
Direct-acting antivirals for RSV treatment, a review
Antiviral Research·2024· 33 cited
Spiro-Azetidine Oxindoles as Long-Acting Injectables for Pre-Exposure Prophylaxis against Respiratory Syncytial Virus Infections
Journal of Medicinal Chemistry·2024· 11 cited
Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML
Journal of Medicinal Chemistry·2024· 6 citedOpen Access
Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors
ACS Medicinal Chemistry Letters·2024· 3 citedOpen Access
Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor
Communications Biology·2023· 31 citedOpen Access
From Oxetane to Thietane: Extending the Antiviral Spectrum of 2′-Spirocyclic Uridines by Substituting Oxygen with Sulfur
ACS Medicinal Chemistry Letters·2022· 9 citedOpen Access
<i>N</i>-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia
Journal of Medicinal Chemistry·2022· 16 citedOpen Access
Divide and Conquer. Pocket-Opening Mixed-Solvent Simulations in the Perspective of Docking Virtual Screening Applications for Drug Discovery
Journal of Chemical Information and Modeling·2022· 11 citedOpen Access
Abstract 1256: JNJ-74856665, a novel DHODH inhibitor, mediates potent anti-leukemic activity and differentiation <i>in vitro</i> and <i>in vivo</i>
Cancer Research·2021· 7 cited
A carboxylic acid isostere screen of the DHODH inhibitor Brequinar
Bioorganic & Medicinal Chemistry Letters·2020· 8 citedOpen Access
FEP+ calculations predict a stereochemical SAR switch for first-in-class indoline NIK inhibitors for multiple myeloma
Future Drug Discovery·2020· 4 citedOpen Access
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Frequent Co-authors

Ansgar Schuffenhauer(14), Pierre Acklin(10), Khalil Azzaoui(8), Maxim Popov(5), Michael Engels(4), Jérôme Hert(4), Peter Willett(4), David J. Wilton(4), Ulrich Schopfer(4), Axel Wollmer(3), Jeremy L. Jenkins(3), Nathan Brown(3), Peter Meier(3), Steffen Renner(3), Jean‐Marc Neefs(3), J. Schlitter(2), Péter Krüger(2), Philipp Floersheim(2), Eric Vangrevelinghe(2), Andreas L. Marzinzik(2)