Philipp Floersheim

Novartis (Switzerland) — Switzerland

Neuroscience · Life Sciences

20h-index1.4kcitations29works0.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Neuroscience and Neuropharmacology Research(7), Computational Drug Discovery Methods(5), Receptor Mechanisms and Signaling(5), Analytical Chemistry and Chromatography(4), Estrogen and related hormone effects(3)

Publications29 total

6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2011· 22 cited
2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes
Bioorganic & Medicinal Chemistry Letters·2011· 32 citedOpen Access
Drug Design, in Vitro Pharmacology, and Structure−Activity Relationships of 3-Acylamino-2-aminopropionic Acid Derivatives, a Novel Class of Partial Agonists at the Glycine Site on the<i>N</i>-Methyl-<scp>d</scp>-aspartate (NMDA) Receptor Complex
Journal of Medicinal Chemistry·2009· 33 cited
Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABAB receptors
Bioorganic & Medicinal Chemistry Letters·2007· 62 citedOpen Access
SAR of the arylpiperazine moiety of obeline somatostatin sst1 receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2007· 9 citedOpen Access
Selective Estrogen Receptor Modulators with Conformationally Restricted Side Chains. Synthesis and Structure−Activity Relationship of ERα-Selective Tetrahydroisoquinoline Ligands
Journal of Medicinal Chemistry·2004· 65 citedOpen Access
Estrogen Receptor Modulators:  Identification and Structure−Activity Relationships of Potent ERα-Selective Tetrahydroisoquinoline Ligands
Journal of Medicinal Chemistry·2003· 88 citedOpen Access
Similarity Metrics for Ligands Reflecting the Similarity of the Target Proteins.
ChemInform·2003· 2 cited
Chemogenomics knowledge-based strategies in drug discovery
Drug News & Perspectives·2003· 40 cited
Similarity Metrics for Ligands Reflecting the Similarity of the Target Proteins
Journal of Chemical Information and Computer Sciences·2002· 249 cited
Untitled
Angewandte Chemie·2002· 13 cited
NMR Reporter Screening for the Detection of High-Affinity Ligands
Angewandte Chemie International Edition·2002· 98 cited
Toward Selective ERβ Agonists for Central Nervous System Disorders:  Synthesis and Characterization of Aryl Benzthiophenes
Journal of Medicinal Chemistry·2002· 86 citedOpen Access
Inhibition of cyclosporin-resistant B-cell antigen responses by pyrazoles: a tool for the identification of novel molecular mechanisms of B-cell activation
Transplantation Proceedings·2001· 2 cited
Discovery and characterization of non-competitive antagonists of group I metabotropic glutamate receptors
Il Farmaco·2001· 29 cited
Chiral Resolution, Pharmacological Characterization, and Receptor Docking of the Noncompetitive mGlu1 Receptor Antagonist (±)-2-Hydroxyimino- 1a,2-dihydro-1<i>H</i>-7-oxacyclopropa[<i>b</i>]naphthalene-7a-carboxylic Acid Ethyl Ester
Journal of Medicinal Chemistry·2000· 22 citedOpen Access
The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors
Journal of Biological Chemistry·2000· 267 citedOpen Access
Use of organic solvents and small molecules for locating binding sites on proteins in solution*
Journal of Biomolecular NMR·1999· 26 cited
ChemInform Abstract: Pyrazole Bioisosteres of Leflunomide as B‐Cell Immunosuppressants for Xenotransplantation and Chronic Rejection: Scope and Limitations.
ChemInform·1998
Pyrazole Bioisosteres of Leflunomide as B-Cell Immunosuppressants for Xenotransplantation and Chronic Rejection:  Scope and Limitations
Journal of Medicinal Chemistry·1998· 18 citedOpen Access
page 1 of 2Next →

Frequent Co-authors

Natacha Stoehr(3), Peter J. Flor(3), F. Gasparini(3), Ansgar Schuffenhauer(3), Edgar Jacoby(3), Konstanze Hurth(3), Serge Bischoff(3), Joerg Kallen(3), Gideon Shapiro(3), Albert Enz(3), Christos Papageorgiou(3), Rainer Albert(3), Elsebeth Andersen(3), Valerie Hungerford(3), Max H. Schreier(3), Adriana Pagano(2), Christine Stierlin(2), Micheline Heinrich(2), Ivo Vranesic(2), Rainer Kühn(2)