Konstanze Hurth

Novartis (Switzerland) — Switzerland

Medicine · Health Sciences

13h-index724citations24works4.02yr avg
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Research Topics

Neuroendocrine Tumor Research Advances(8), Receptor Mechanisms and Signaling(6), HER2/EGFR in Cancer Research(5), Monoclonal and Polyclonal Antibodies Research(5), Alzheimer's disease research and treatments(3)

Publications24 total

A Mild Rhodium‐Catalyzed Asymmetric 1,4‐Conjugate Addition of Organoboranes to α‐Substituted Heterocyclic Acrylates for Use in Pharmaceutical Products
Helvetica Chimica Acta·2025· 1 cited
Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches
Journal of Medicinal Chemistry·2024· 7 citedOpen Access
Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β
Nature Communications·2023· 21 citedOpen Access
Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer’s Disease
Journal of Medicinal Chemistry·2021· 32 citedOpen Access
Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360
Journal of Medicinal Chemistry·2021· 13 citedOpen Access
The <scp>BACE</scp> ‐1 inhibitor <scp>CNP</scp> 520 for prevention trials in Alzheimer's disease
EMBO Molecular Medicine·2018· 168 citedOpen Access
Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2018· 11 citedOpen Access
ChemInform Abstract: Regioselective Nitration of 3‐Fluoro‐2‐Substituted Benzoic Acids.
ChemInform·2015
Regioselective nitration of 3-fluoro-2-substituted benzoic acids
Tetrahedron Letters·2015· 5 cited
<scp>AQW</scp>051, a novel, potent and selective<scp>α</scp>7 nicotinic<scp>ACh</scp>receptor partial agonist: pharmacological characterization and phase<scp>I</scp>evaluation
British Journal of Pharmacology·2014· 32 citedOpen Access
AQW051, a novel, potent and selective nicotinic acetylcholine receptor α7 partial agonist: Pharmacological characterisation and Phase I evaluation in healthy subjects
2014
Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABAA receptor
Bioorganic & Medicinal Chemistry Letters·2010· 5 citedOpen Access
Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst3 receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2010· 16 citedOpen Access
Gamma-lactams—A novel scaffold for highly potent and selective α7 nicotinic acetylcholine receptor agonists
Bioorganic & Medicinal Chemistry Letters·2009· 32 citedOpen Access
Discovery of novel non-peptidic β-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2009· 11 citedOpen Access
Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst1 receptor
Bioorganic & Medicinal Chemistry Letters·2007· 10 citedOpen Access
SAR of the arylpiperazine moiety of obeline somatostatin sst1 receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2007· 9 citedOpen Access
Identification and SAR of potent and selective non-peptide obeline somatostatin sst1 receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2007· 10 citedOpen Access
SRA880, in vitro characterization of the first non-peptide somatostatin sst1 receptor antagonist
Neuroscience Letters·2004· 36 cited
Agonist properties of putative small-molecule somatostatin sst2 receptor-selective antagonists
European Journal of Pharmacology·2003· 26 cited
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Frequent Co-authors

Daniël Hoyer(11), Daniel Langenegger(8), Thomas Troxler(7), Jean‐Michel Rondeau(6), Marina Tintelnot‐Blomley(5), Philippe Schoeffter(5), Albert Enz(5), Ulf Neumann(4), Laura H. Jacobson(4), Rainer Machauer(4), Siem J. Veenstra(4), Heinrich Rueeger(4), Caroline Nunn(4), Dominik Feuerbach(4), Peter Neumann(4), Matthias Staufenbiel(3), Nicole Pezous(3), Cristina López López(3), Philipp Floersheim(3), Rainer Lueoend(3)