Rainer Lueoend

Novartis (Switzerland) — Switzerland

Medicine · Health Sciences

8h-index346citations15works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(7), Computational Drug Discovery Methods(7), Drug Transport and Resistance Mechanisms(5), Cholinesterase and Neurodegenerative Diseases(3), Organometallic Complex Synthesis and Catalysis(2)

Publications15 total

Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase
Journal of Medicinal Chemistry·2023· 6 citedOpen Access
Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer’s Disease
Journal of Medicinal Chemistry·2021· 32 citedOpen Access
Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360
Journal of Medicinal Chemistry·2021· 13 citedOpen Access
Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2018· 11 citedOpen Access
A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice
Molecular Neurodegeneration·2015· 109 citedOpen Access
BACE inhibitor NB-360 reveals strong reduction of amyloid-β generation, robust blockade of amyloid deposition and lowering of neuroinflammation in APP transgenic mice
2015
P4‐363: THE BACE INHIBITOR NB‐360 HAS EXCELLENT BRAIN PENETRATION AND EFFICACY ON AMYLOID‐B LOAD IN ANIMAL MODELS
Alzheimer s & Dementia·2014· 1 citedOpen Access
Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-peptides
Bioorganic & Medicinal Chemistry Letters·2013· 24 citedOpen Access
Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides
Journal of Medicinal Chemistry·2012· 98 citedOpen Access
Assessment of the active-site requirements of 5-aminolevulinic acid dehydratase: evaluation of substrate and product analogs as competitive inhibitors
The Journal of Organic Chemistry·1992· 32 cited
ChemInform Abstract: Michael Reactions of α‐Unsubstituted Trisubstituted 1H‐Pyrroles.
ChemInform·1991
ChemInform Abstract: Cyclometalated Compounds of Platinum(II) with Two Different C,N‐Aromatic Ligands.
ChemInform·1989
ChemInform Abstract: Absorption Spectra, Luminescence Properties, and Electrochemical Behavior of Two New Cyclometalated Platinum(II) Complexes.
ChemInform·1989
ChemInform Abstract: α‐Nitro Keto Hydrazone and Keto Imine Dianions. Synthetic Equivalents for the Nitroalkene d3 Synthon.
ChemInform·1988
.alpha.-Nitro keto hydrazone and keto imine dianions. Synthetic equivalents for the nitroalkene d3 synthon
The Journal of Organic Chemistry·1988· 20 cited

Frequent Co-authors

Ulf Neumann(8), Heinrich Rueeger(8), Rainer Machauer(8), Laura H. Jacobson(8), Matthias Staufenbiel(7), Marina Tintelnot‐Blomley(6), Grit Laue(5), Jean‐Michel Rondeau(5), Siem J. Veenstra(5), Karen Beltz(4), Barbara Vogg(3), Peter Schmid(3), Wilfried Frieauff(3), Derya R. Shimshek(3), Konstanze Hurth(3), Markus Voegtle(3), Siem Jacob Veenstra(2), Henrik Möbitz(2), Sandrine Desrayaud(2), Reinhard Neier(2)