Rainer Machauer

Novartis (China) — China

Computer Science · Physical Sciences

18h-index1.1kcitations32works9.32yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Computational Drug Discovery Methods(12), Alzheimer's disease research and treatments(11), Chemical Synthesis and Analysis(9), Drug Transport and Resistance Mechanisms(6), Cholinesterase and Neurodegenerative Diseases(5)

Publications32 total

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement
Journal of Medicinal Chemistry·2025
Discovery and Optimization of Selective Inhibitors of Large Tumor Suppressor Kinases LATS1 and 2 for In Vivo Investigation of the Hippo-YAP Pathway in Tissue Regeneration
Journal of Medicinal Chemistry·2025· 1 cited
NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo
Cell stem cell·2024· 27 cited
JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS<sup>G12C</sup> for the Treatment of Solid Tumors
Journal of Medicinal Chemistry·2022· 84 citedOpen Access
Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer’s Disease
Journal of Medicinal Chemistry·2021· 32 citedOpen Access
Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360
Journal of Medicinal Chemistry·2021· 13 citedOpen Access
Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain
ACS Chemical Biology·2019· 26 cited
The β‐secretase (BACE) inhibitor NB‐360 in preclinical models: From amyloid‐β reduction to downstream disease‐relevant effects
British Journal of Pharmacology·2019· 28 citedOpen Access
The BACE inhibitor NB-360 in preclinical models: From β-amyloid reduction to downstream disease-relevant effects
The Novartis Repository (Novartis)·2019
The <scp>BACE</scp> ‐1 inhibitor <scp>CNP</scp> 520 for prevention trials in Alzheimer's disease
EMBO Molecular Medicine·2018· 168 citedOpen Access
Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2018· 11 citedOpen Access
Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach
ACS Medicinal Chemistry Letters·2017· 49 citedOpen Access
Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach
ACS Medicinal Chemistry Letters·2016· 62 citedOpen Access
Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice
Scientific Reports·2016· 66 citedOpen Access
A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice
Molecular Neurodegeneration·2015· 109 citedOpen Access
BACE inhibitor NB-360 reveals strong reduction of amyloid-β generation, robust blockade of amyloid deposition and lowering of neuroinflammation in APP transgenic mice
2015
Tracing BACE : Synthesis and evaluation of beta-secretase inhibitors as ligands for PET imaging
Journal of Labelled Compounds and Radiopharmaceuticals·2015
P4‐363: THE BACE INHIBITOR NB‐360 HAS EXCELLENT BRAIN PENETRATION AND EFFICACY ON AMYLOID‐B LOAD IN ANIMAL MODELS
Alzheimer s & Dementia·2014· 1 citedOpen Access
Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-peptides
Bioorganic & Medicinal Chemistry Letters·2013· 24 citedOpen Access
Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides
Journal of Medicinal Chemistry·2012· 98 citedOpen Access
page 1 of 2Next →

Frequent Co-authors

Ulf Neumann(16), Marina Tintelnot‐Blomley(11), Laura H. Jacobson(10), Siem J. Veenstra(10), Heinrich Rueeger(10), Matthias Staufenbiel(10), Jean‐Michel Rondeau(10), Rainer Lueoend(8), Derya R. Shimshek(7), Karen Beltz(7), Grit Laue(5), Konstanze Hurth(4), Wilfried Frieauff(4), Barbara Vogg(4), Henrik Möbitz(4), Sandrine Desrayaud(4), Stephen F. Martin(4), Philipp Holzer(4), Clemens Scheufler(4), Claudia Betschart(4)