Alfredo Megaro

Neuroscience · Life Sciences

11h-index466citations16works15.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(7), Alzheimer's disease research and treatments(6), Ion channel regulation and function(5), Genetic Neurodegenerative Diseases(4), Parkinson's Disease Mechanisms and Treatments(3)

Publications16 total

Oligomeric alpha-synuclein causes early synaptic dysfunction of the corticostriatal pathway associated with non-motor symptoms
npj Parkinson s Disease·2025· 5 citedOpen Access
Fully automated measurement of plasma Aβ42/40 and p‐tau181: Analytical robustness and concordance with cerebrospinal fluid profile along the Alzheimer's disease continuum in two independent cohorts
Alzheimer s & Dementia·2024· 36 citedOpen Access
Locally Synthetized 17-β-Estradiol Reverses Amyloid-β-42-Induced Hippocampal Long-Term Potentiation Deficits
International Journal of Molecular Sciences·2024· 4 citedOpen Access
Automatic assessment of classical Alzheimer’s disease biomarkers in paired cerebrospinal fluid and plasma samples
Alzheimer s & Dementia·2023Open Access
An activator of voltage-gated K <sup>+</sup> channels Kv1.1 as a therapeutic candidate for episodic ataxia type 1
Proceedings of the National Academy of Sciences·2023· 17 citedOpen Access
Non-competitive AMPA glutamate receptors antagonism by perampanel as a strategy to counteract hippocampal hyper-excitability and cognitive deficits in cerebral amyloidosis
Neuropharmacology·2022· 16 cited
Interleukin-17 affects synaptic plasticity and cognition in an experimental model of multiple sclerosis
Cell Reports·2021· 81 citedOpen Access
Interleukin-17 axis in the modulation of cortical and subcortical synaptic plasticity across disease stages in experimental multiple sclerosis
Journal of the Neurological Sciences·2021
Dopamine-dependent early synaptic and motor dysfunctions induced by α-synuclein in the nigrostriatal circuit
Brain·2021· 116 citedOpen Access
An Unbalanced Synaptic Transmission: Cause or Consequence of the Amyloid Oligomers Neurotoxicity?
International Journal of Molecular Sciences·2021· 68 citedOpen Access
From Synaptic Dysfunction to Neuroprotective Strategies in Genetic Parkinson’s Disease: Lessons From LRRK2
Frontiers in Cellular Neuroscience·2020· 20 citedOpen Access
Electromechanical coupling of the Kv1.1 voltage-gated K+ channel is fine-tuned by the simplest amino acid residue in the S4-S5 linker
Pflügers Archiv - European Journal of Physiology·2020· 3 citedOpen Access
Low doses of Perampanel protect striatal and hippocampal neurons against in vitro ischemia by reversing the ischemia-induced alteration of AMPA receptor subunit composition
Neurobiology of Disease·2020· 20 citedOpen Access
Striatal spreading depolarization: Possible implication in levodopa‐induced dyskinetic‐like behavior
Movement Disorders·2019· 11 citedOpen Access
Identification of a New de Novo Mutation Underlying Regressive Episodic Ataxia Type I
Frontiers in Neurology·2018· 12 citedOpen Access
Structure, Gating and Basic Functions of the Ca2+-activated K Channel of Intermediate Conductance
Current Neuropharmacology·2018· 57 citedOpen Access

Frequent Co-authors

Miriam Sciaccaluga(10), Alessandro Tozzi(9), Laura Bellingacci(8), Cinzia Costa(8), Paolo Calabresi(7), Massimiliano Di Filippo(7), Andrea Mancini(6), Petra Mazzocchetti(6), Lorenzo Gaetani(4), Lucilla Parnetti(4), Mauro Pessia(4), Antonella Cardinale(3), Valentina Durante(3), Davide Chiasserini(3), Maria Teresa Viscomi(3), Giovanni Bellomo(3), Paola Imbrici(3), Maria Cristina D’Adamo(3), Fabrizio Gardoni(2), Barbara Picconi(2)