James D. Lechleiter

The University of Texas Health Science Center at San Antonio — United States

Neuroscience · Life Sciences

44h-index8.6kcitations117works2.32yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(21), Mitochondrial Function and Pathology(19), Ion channel regulation and function(16), Adenosine and Purinergic Signaling(15), Neuroinflammation and Neurodegeneration Mechanisms(13)

Publications117 total

Loss of CD98HC phosphorylation by ATM impairs antiporter trafficking and drives glutamate toxicity in Ataxia telangiectasia
Nature Communications·2025· 2 citedOpen Access
<b>β</b> -hydroxybutyrate enhances brain metabolism in normoglycemia and hyperglycemia, providing cerebroprotection in a mouse stroke model
Journal of Cerebral Blood Flow & Metabolism·2025· 3 citedOpen Access
β-Hydroxybutyrate enhances brain metabolism in normoglycemia and hyperglycemia, providing cerebroprotection in a mouse stroke model
2025Open Access
Quinolinic acid potentially links kidney injury to brain toxicity
JCI Insight·2025· 8 citedOpen Access
SNX19 contributes to neurodegeneration by disrupting the endolysosomal system in neurons
Alzheimer s & Dementia·2024Open Access
HADHA Regulates Respiratory Complex Assembly and Couples FAO and OXPHOS
Advanced Science·2024· 5 citedOpen Access
Identification of a specific APOE transcript and functional elements associated with Alzheimer’s disease
Molecular Neurodegeneration·2024· 2 citedOpen Access
Lack of Interactions Between Alteplase/Tenecteplase and the Adenosine A1R/A3R Agonist AST-004
Stroke·2024· 1 cited
Quinolinic acid links kidney injury to brain toxicity
2024· 2 citedOpen Access
Corrigendum: Adenosine A1R/A3R agonist AST-004 reduces brain infarction in mouse and rat models of acute ischemic stroke
Frontiers in Stroke·2024Open Access
Identification of a specific APOE transcript and functional elements associated with Alzheimer’s disease
2023Open Access
Acute Treatment with the M-Channel (Kv7, KCNQ) Opener Retigabine Reduces the Long-Term Effects of Repetitive Blast Traumatic Brain Injuries
Neurotherapeutics·2023· 14 citedOpen Access
Adenosine A1R/A3R agonist AST-004 reduces brain infarction in mouse and rat models of acute ischemic stroke
Frontiers in Stroke·2022· 6 citedOpen Access
Ca2+ signalling system initiated by endoplasmic reticulum stress stimulates PERK activation
Cell Calcium·2022· 19 citedOpen Access
Adenosine A1R/A3R Agonist AST-004 Reduces Brain Infarction in Mouse and Rat Models of Acute Ischemic Stroke
2022· 1 citedOpen Access
Adenosine A1R/A3R (Adenosine A1 and A3 Receptor) Agonist AST-004 Reduces Brain Infarction in a Nonhuman Primate Model of Stroke
Stroke·2021· 33 citedOpen Access
HspB1 Overexpression Improves Life Span and Stress Resistance in an Invertebrate Model
The Journals of Gerontology Series A·2021· 17 citedOpen Access
Hyperglycemia-Induced Mitochondrial Dysfunction in Kidney and Brain Are Protected by β-Hydroxybutyrate Treatment
Journal of the American Society of Nephrology·2021
Neuroprotective Roles of the Adenosine A3 Receptor Agonist AST-004 in Mouse Model of Traumatic Brain Injury
Neurotherapeutics·2021· 20 citedOpen Access
San Antonio Nathan Shock Center: your one-stop shop for aging research
GeroScience·2021· 6 citedOpen Access
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Frequent Co-authors

Patricia Camacho(11), Deborah Holstein(10), David E. Clapham(6), Wei Zheng(6), Lora Talley Watts(4), Da‐Ting Lin(4), Steven Girard(3), Jun Wu(3), Yidong Bai(3), Linu M. John(3), N. Sayre(3), Paul Brehm(3), Mark S. Shapiro(3), Brian Herman(2), Ernest G. Peralta(2), Roger Paredes(2), Julie C. Etzler(2), Jonathan A. Javitch(2), Aurelio Galli(2), Stacy A. Hussong(2)