Mengze Zhou

China Pharmaceutical University — China

Medicine · Health Sciences

17h-index804citations39works4.72yr avg
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Research Topics

Gout, Hyperuricemia, Uric Acid(11), Adenosine and Purinergic Signaling(10), Inflammasome and immune disorders(7), Urticaria and Related Conditions(3), Pharmacological Receptor Mechanisms and Effects(3)

Publications39 total

Unraveling mode-mode interaction drives spectral performance in multi-mode photonic molecules
Optics Express·2025Open Access
Discovery of Novel P2Y <sub>14</sub> R Inhibitors for Ameliorating Liver Fibrosis by Suppressing Hepatic Stellate Cell Activation
Journal of Medicinal Chemistry·2025
Targeting P2Y14R alleviates platelet-induced NET formation and venous thrombosis through PKA/AKAP13/RhoA axis
European Heart Journal·2025· 3 cited
Attributes novel drug candidate: Constitutive GPCR signal bias mediated by purinergic receptors
Pharmacology & Therapeutics·2025· 4 cited
P2Y14R activation facilitates liver regeneration via CREB/DNMT3b/Dact-2/β-Catenin signals in acute liver failure
Acta Pharmaceutica Sinica B·2025· 2 citedOpen Access
Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis: Erratum
International Journal of Biological Sciences·2024Open Access
Identification of 6-Fluorine-Substituted Coumarin Analogues as POLRMT Inhibitors with High Potency and Safety for Treatment of Pancreatic Cancer
Journal of Medicinal Chemistry·2024· 4 cited
Discovery of a Series of 4-Amide-thiophene-2-carboxyl Derivatives as Highly Potent P2Y<sub>14</sub> Receptor Antagonists for Inflammatory Bowel Disease Treatment
Journal of Medicinal Chemistry·2024· 9 cited
Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses
Acta Pharmaceutica Sinica B·2024· 16 citedOpen Access
Comprehensive insights into potential roles of purinergic P2 receptors on diseases: Signaling pathways involved and potential therapeutics
Journal of Advanced Research·2024· 9 citedOpen Access
Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cβ/store-operated calcium entry/calreticulin/scavenger receptor A pathways
European Heart Journal·2023· 42 citedOpen Access
Network pharmacology-based analysis of Jin-Si-Wei on the treatment of Alzheimer's disease
Journal of Ethnopharmacology·2023· 19 cited
Polysaccharide from Strongylocentrotus nudus eggs regulates intestinal epithelial autophagy through CD36/PI3K-Akt pathway to ameliorate inflammatory bowel disease
International Journal of Biological Macromolecules·2023· 17 cited
Structure-based virtual screening for discovery of paederosidic acid from Paederia scandens as novel P2Y14R antagonist
Phytomedicine·2023· 9 cited
Discovery of Selective P2Y<sub>6</sub>R Antagonists with High Affinity and <i>In Vivo</i> Efficacy for Inflammatory Disease Therapy
Journal of Medicinal Chemistry·2023· 25 citedOpen Access
Structure-Based Virtual Screening for Discovery of Paederosidic Acid from Paederia Scandens as Novel P2Y14R Antagonist
SSRN Electronic Journal·2023Open Access
HQL6 serves as a novel P2Y14 receptor antagonist to ameliorate acute gouty arthritis through inhibiting macrophage pyroptosis
International Immunopharmacology·2022· 8 cited
Discovery of a Series of 5-Amide-1<i>H</i>-pyrazole-3-carboxyl Derivatives as Potent P2Y<sub>14</sub>R Antagonists with Anti-Inflammatory Characters
Journal of Medicinal Chemistry·2022· 16 citedOpen Access
GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils
Frontiers in Immunology·2022· 22 citedOpen Access
Cardiovascular Protective Effects of Plant Polysaccharides: A Review
Frontiers in Pharmacology·2021· 33 citedOpen Access
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Frequent Co-authors

Qinghua Hu(31), Huanqiu Li(16), Kun Hao(8), Yehong Li(8), Sheng Tian(8), Wenjiao Jiang(5), Yifan Zhu(5), Hanwen Li(4), Shumin Ye(4), Chunxiao Liu(4), Cheng Jiang(4), Tianqi Mao(4), Xinli Dong(3), Hui Ji(3), Chunxiao Liu(3), Li Yin(3), Yanshuo Guo(3), Jialong Qian(3), Xiping Yang(2), Yadong Chen(2)