Douglas S. Johnson

Biogen (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

40h-index5.9kcitations117works5.52yr avg
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Research Topics

Chemical Synthesis and Analysis(18), Click Chemistry and Applications(17), Alzheimer's disease research and treatments(15), Cannabis and Cannabinoid Research(14), DNA and Nucleic Acid Chemistry(14)

Publications116 total

Identification of aryl hydrocarbon receptor as a functional target that enhances astrocytic ApoE secretion
Cell chemical biology·2026
Chemoproteomic Profiling of Clickable Fumarate Probes for Target Identification and Mechanism of Action Studies
ACS Chemical Biology·2025· 2 cited
Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer’s Disease
Journal of Medicinal Chemistry·2024· 5 citedOpen Access
Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis
Journal of Medicinal Chemistry·2024· 15 citedOpen Access
Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input
Cell chemical biology·2023· 41 citedOpen Access
Utility of chemical probes for mass spectrometry based chemical proteomics
Elsevier eBooks·2021
Contributors
Elsevier eBooks·2021
Linked PDF of Table of Contents
Synlett·2021Open Access
Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity
ChemBioChem·2021· 8 cited
Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE
Cell chemical biology·2020· 26 cited
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease
Nature·2020· 361 citedOpen Access
Fluorophosphonate‐Based Degrader Identifies Degradable Serine Hydrolases by Quantitative Proteomics
ChemBioChem·2020· 5 cited
Photoaffinity Labeling and Quantitative Chemical Proteomics Identify Liver X Receptor β as the Functional Target of Enhancers of Astrocytic Apolipoprotein E
SSRN Electronic Journal·2020Open Access
Studies on the stability and stabilization of trans-cyclooctenes through radical inhibition and silver (I) metal complexation
Tetrahedron·2019· 37 citedOpen Access
PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor
ACS Chemical Biology·2019· 152 cited
Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10–2474
ACS Chemical Biology·2019· 45 cited
Table of Contents
Journal of Nutrition Education and Behavior·2018Open Access
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation
Journal of Medicinal Chemistry·2018· 78 citedOpen Access
Photochemical syntheses, transformations, and bioorthogonal chemistry of<i>trans</i>-cycloheptene and sila<i>trans</i>-cycloheptene Ag(<scp>i</scp>) complexes
Chemical Science·2018· 44 citedOpen Access
Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase
Journal of Medicinal Chemistry·2017· 75 citedOpen Access
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Frequent Co-authors

Christopher W. am Ende(12), Benjamin F. Cravatt(11), Cory M. Stiff(10), Dale L. Boger(8), Kay Ahn(7), Martin Pettersson(7), Kelly R. Bales(7), Marya Liimatta(6), Yue‐Ming Li(6), Christina J. Crump(5), T. Eric Ballard(5), Gregory W. Kauffman(5), David Beidler(4), Eranthie Weerapana(4), Sarah E. Smith(4), Tyzoon Nomanbhoy(4), Nikolay Pozdnyakov(4), Michael A. Brodney(4), Zhen Huang(4), Benjamin A. Fish(4)