Nikolay Pozdnyakov

Pfizer (United States) — United States

Medicine · Health Sciences

16h-index928citations31works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(12), Computational Drug Discovery Methods(6), Drug Transport and Resistance Mechanisms(6), Retinal Development and Disorders(5), Cholinesterase and Neurodegenerative Diseases(5)

Publications31 total

Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury
Journal of Neuroinflammation·2018· 57 citedOpen Access
Additional file 2: of Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury
Figshare·2018Open Access
Additional file 1: of Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury
Figshare·2018Open Access
Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity
Brain·2015· 64 citedOpen Access
P4‐315: Evaluating amyloid‐beta processing using novel gamma‐secretase modulators in preclinical animal models
Alzheimer s & Dementia·2015· 1 citedOpen Access
P4‐234: IMPROVED VASCULAR REACTIVITY AND REDUCED CEREBRAL AMYLOID ANGIOPATHY FOLLOWING PASSIVE IMMUNOTHERAPY IN TRANSGENIC MICE
Alzheimer s & Dementia·2014
Design, Synthesis, and Pharmacological Evaluation of a Novel Series of Pyridopyrazine-1,6-dione γ-Secretase Modulators
Journal of Medicinal Chemistry·2014· 29 citedOpen Access
P4–299: Chronic ponezumab treatment reduces brain vascular amyloid in the PS1APP mouse model
Alzheimer s & Dementia·2013
P4–300: Developing an <i>in vitro</i>‐<i>in vivo</i> model to study the impact of increasing brain APOE levels on cardiovascular safety
Alzheimer s & Dementia·2013
P4–298: Understanding the target and evaluating the consequences of gamma‐secretase modulation from <i>in vitro</i> models to higher‐order species
Alzheimer s & Dementia·2013Open Access
O1–11–01: Gamma‐secretase inhibitor (GSI) and modulator (GSM) photoaffinity probes reveal distinct binding sites on presenilin
Alzheimer s & Dementia·2013
Clickable gamma‐secretase modulator photoaffinity probes bind distinct sites on presenilin
The FASEB Journal·2013
γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin
Journal of Biological Chemistry·2013· 103 citedOpen Access
BMS-708,163 Targets Presenilin and Lacks Notch-Sparing Activity
Biochemistry·2012· 93 citedOpen Access
Development of clickable active site-directed photoaffinity probes for γ-secretase
Bioorganic & Medicinal Chemistry Letters·2012· 27 citedOpen Access
Pharmacological Assessment of &amp;lt;i&amp;gt;γ&amp;lt;/i&amp;gt;-Secretase Activity from Rodent and Human Brain
Neuroscience &amp Medicine·2012· 3 citedOpen Access
Piperidine Acetic Acid Based γ-Secretase Modulators Directly Bind to Presenilin-1
ACS Chemical Neuroscience·2011· 62 citedOpen Access
Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014
Bioorganic & Medicinal Chemistry Letters·2010· 31 citedOpen Access
Diamide amino-imidazoles: A novel series of γ-secretase inhibitors for the treatment of Alzheimer’s disease
Bioorganic & Medicinal Chemistry Letters·2010· 14 citedOpen Access
Pharmacodynamics and Pharmacokinetics of the γ-Secretase Inhibitor PF-3084014
Journal of Pharmacology and Experimental Therapeutics·2010· 50 cited
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Frequent Co-authors

Kelly R. Bales(14), Kathleen M. Wood(12), Martin Pettersson(9), Ari Sitaramayya(9), Thomas A. Lanz(8), Douglas S. Johnson(8), Alexander R. Margulis(7), Christina J. Crump(6), Yue‐Ming Li(6), YeQing Pi(6), Tarek A. Samad(6), Tracy M. Brown(5), Charles E. Nolan(5), K. Richter(5), James E. Finley(5), Barbara Tate(5), Christine Oborski(5), Sharon O'Neill(4), Akiko Yoshida(4), Stacey L. Becker(4)