William F. Michne

Chemistry · Physical Sciences

12h-index302citations46works0.02yr avg
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Research Topics

Carbohydrate Chemistry and Synthesis(6), Synthesis and Reactions of Organic Compounds(6), Chemical Synthesis and Analysis(4), Synthesis and pharmacology of benzodiazepine derivatives(4), Axial and Atropisomeric Chirality Synthesis(4)

Publications46 total

Lead Discovery: The Process
2010· 3 cited
Faculty Opinions recommendation of Functional group contributions to drug-receptor interactions.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2009
Faculty Opinions recommendation of Do structurally similar ligands bind in a similar fashion?
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2009
Faculty Opinions recommendation of Assessment of the consistency of medicinal chemists in reviewing sets of compounds.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2009
Faculty Opinions recommendation of A comparison of physiochemical property profiles of development and marketed oral drugs.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2009
Faculty Opinions recommendation of Do structurally similar molecules have similar biological activity?
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2009
Faculty Opinions recommendation of Molecular complexity and its impact on the probability of finding leads for drug discovery.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2009
The 2006 Benjamin Franklin Medal in Chemistry presented to Samuel J. Danishefsky, Ph.D.
Journal of the Franklin Institute·2008
Editorial [Hot Topic: Chemical Effectors in Drug Discovery (Guest Editor: William F. Michne)]
Current Topics in Medicinal Chemistry·2005
The Value of Chemical Genetics in Drug Discovery
Methods and principles in medicinal chemistry·2004· 6 cited
Molecular modeling and mutagenesis of the ligand‐binding pocket of the mGlu3 subtype of metabotropic glutamate receptor
Journal of Neurochemistry·2003· 30 cited
In vitro characterization of a novel series of platelet-derived growth factor receptor tyrosine kinase inhibitors
Biochemical Pharmacology·1996· 19 cited
Design and synthesis of a β‐strand inducer Application to ICAM‐1/LFA‐1 mediated cellular adhesion
International journal of peptide & protein research·1996· 17 cited
Keto/Enol Epoxy Steroids as HIV-1 Tat Inhibitors: Structure-Activity Relationships and Pharmacophore Localization
Journal of Medicinal Chemistry·1995· 21 citedOpen Access
Novel Inhibitors of the Nuclear Factor of Activated T Cells (NFAT)-Mediated Transcription of .beta.-Galactosidase: Potential Immunosuppressive and Antiinflammatory Agents
Journal of Medicinal Chemistry·1995· 20 cited
Novel Inhibitors of Potassium Ion Channels on Human T Lymphocytes
Journal of Medicinal Chemistry·1995· 33 citedOpen Access
ChemInform Abstract: Practical Synthesis of the Enantiomers of Hydroxychloroquine.
ChemInform·1995
A practical synthesis of the enantiomers of hydroxychloroquine
Tetrahedron Asymmetry·1994· 14 cited
ChemInform Abstract: 4,5‐Dihydro‐1‐phenyl‐1H‐2,4‐benzodiazepines: Novel Antiarrhythmic Agents.
ChemInform·1994
ChemInform Abstract: Keto/Enol Epoxy Steroids: A New Structural Class of HIV‐1 Tat Inhibitors.
ChemInform·1993
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Frequent Co-authors

Carolyn A. Weigelt(7), Noel F. Albertson(7), Mary F. Stansberry(5), Joseph D. Schroeder(4), Stephen J. Michalec(4), Mark A. Sanner(4), Joseph W. Guiles(3), Adi M. Treasurywala(3), T. R. Bailey(3), Anne K. Pierson(3), Rudolph K. Kullnig(3), Dorothy C. Young(2), Joseph V. Hughes(2), Frank J. Dutko(2), R. L. Salsbury(2), Thomas R. Lewis(2), Franklin J. Rosenberg(2), Paul Blaney(2), Stephen J. Byard(2), Glynis Carr(2)