Joseph V. Hughes

WuXi AppTec (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index2.3kcitations39works0.02yr avg
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Research Topics

Virus-based gene therapy research(23), Virology and Viral Diseases(8), CAR-T cell therapy research(8), Viral Infectious Diseases and Gene Expression in Insects(7), Viral gastroenteritis research and epidemiology(5)

Publications39 total

Limits in virus filtration capability? Impact of virus quality and spike level on virus removal with xenotropic murine leukemia virus
Biotechnology Progress·2014· 11 cited
Impact of virus preparation quality on parvovirus filter performance
Biotechnology and Bioengineering·2012· 27 cited
Effectiveness of Various Processing Steps for Viral Clearance of Therapeutic Proteins: Database Analyses of Commonly Used Steps
Methods in molecular biology·2012· 15 cited
A Pilot Study of <i>In Vivo</i> Liver-Directed Gene Transfer with an Adenoviral Vector in Partial Ornithine Transcarbamylase Deficiency
Human Gene Therapy·2002· 350 cited
Biology of E1-Deleted Adenovirus Vectors in Nonhuman Primate Muscle
Journal of Virology·2001· 34 citedOpen Access
Adenoviral-Mediated Suicide Gene Therapy for Ovarian Cancer
Molecular Therapy·2000· 120 citedOpen Access
Readministration of Adenovirus Vector in Nonhuman Primate Lungs by Blockade of CD40-CD40 Ligand Interactions
Journal of Virology·2000· 59 citedOpen Access
Route of Administration Determines Induction of T-Cell-Independent Humoral Responses to Adeno-Associated Virus Vectors
Molecular Therapy·2000· 113 citedOpen Access
Humoral Immunity to Adeno-Associated Virus Type 2 Vectors following Administration to Murine and Nonhuman Primate Muscle
Journal of Virology·2000· 192 citedOpen Access
A Phase I Study of Adenovirus-Mediated Transfer of the Human Cystic Fibrosis Transmembrane Conductance Regulator Gene to a Lung Segment of Individuals with Cystic Fibrosis
Human Gene Therapy·1999· 151 cited
Repeated administration of adenoviral vectors in lungs of human CD4 transgenic mice treated with blocking CD4 antibody
1999
Stable transgene expression in rod photoreceptors after recombinant adeno-associated virus-mediated gene transfer to monkey retina
Proceedings of the National Academy of Sciences·1999· 240 citedOpen Access
Repeated Administration of Adenoviral Vectors in Lungs of Human CD4 Transgenic Mice Treated with a Nondepleting CD4 Antibody
The Journal of Immunology·1999· 38 citedOpen Access
Evaluation of an E1E4-Deleted Adenovirus Expressing the Herpes Simplex Thymidine Kinase Suicide Gene in Cancer Gene Therapy
Human Gene Therapy·1999· 32 cited
Regulated Delivery of Therapeutic Proteins After in Vivo Somatic Cell Gene Transfer
Science·1999· 308 cited
High-Titer Adeno-Associated Viral Vectors from a Rep/Cap Cell Line and Hybrid Shuttle Virus
Human Gene Therapy·1998· 189 cited
Role of E4 in Eliciting CD4 T-Cell and B-Cell Responses to Adenovirus Vectors Delivered to Murine and Nonhuman Primate Lungs
Journal of Virology·1998· 72 citedOpen Access
Validation of retroviral detection for rodent cell-derived products and gene therapy applications.
PubMed·1996· 6 cited
Keto/Enol Epoxy Steroids as HIV-1 Tat Inhibitors: Structure-Activity Relationships and Pharmacophore Localization
Journal of Medicinal Chemistry·1995· 21 citedOpen Access
Inhibition of the Cellular Rev Response and HIV-1 Replication by 8-Alkyl-2-(4-pyridyl)pyrido[2,3-<i>d</i> pyrimidin-5(8<i>H</i>)-Ones
Antiviral chemistry & chemotherapy·1994· 7 citedOpen Access
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Frequent Co-authors

Terry C. Johnson(15), James M. Wilson(13), Narendra Chirmule(10), Guangping Gao(7), John Tazelaar(7), Steven E. Raper(5), Philip W. Zoltick(4), Michael A. Schnell(4), Stanley G. Rabinowitz(4), Weidong Xiao(3), T. R. Bailey(3), Michael S. Burnham(3), Kathleen J. Propert(2), Susan Magosin(2), Alemseged Truneh(2), Sarah Ehlen Haecker(2), Mauro C. Dal Canto(2), William F. Michne(2), Joseph D. Schroeder(2), Dorothy C. Young(2)