Frédéric Simonin

Biotechnologie et Signalisation Cellulaire — France

Neuroscience · Life Sciences

36h-index6.5kcitations92works4.52yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Neuropeptides and Animal Physiology(57), Receptor Mechanisms and Signaling(54), Pharmacological Receptor Mechanisms and Effects(17), PARP inhibition in cancer therapy(14), DNA Repair Mechanisms(9)

Publications92 total

GPRASP1 deletion in mice abrogates adverse side effects associated with chronic stimulation of Beta2-adrenoceptor
Biomedicine & Pharmacotherapy·2025· 1 citedOpen Access
Multitarget μ-Opioid Receptor Agonists─Neuropeptide FF Receptor Antagonists Induce Potent Antinociception with Reduced Adverse Side Effects
Journal of Medicinal Chemistry·2024· 8 citedOpen Access
Characterization of anti-GASP motif antibodies that inhibit the interaction between GPRASP1 and G protein-coupled receptors
Analytical Biochemistry·2023· 3 citedOpen Access
Bifunctional Opioid-Neuropeptide FF Ligands as Analgesics with Reduced Side Effects
2022Open Access
Bifunctional Opioid-Neuropeptide FF Ligands as Analgesics with Reduced Side Effects
2022Open Access
Behavioral characterization, potential clinical relevance and mechanisms of latent pain sensitization
Pharmacology & Therapeutics·2021· 18 citedOpen Access
Identification of an <i>N</i>-acylated-<sup>D</sup>Arg-Leu-NH<sub>2</sub> Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia
Journal of Medicinal Chemistry·2021· 11 citedOpen Access
Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors
RSC Medicinal Chemistry·2021· 42 citedOpen Access
A bifunctional-biased mu-opioid agonist–neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects
Pain·2018· 42 cited
A Bifunctional Biased Mu Opioid Agonist - Neuropeptide Ff Receptor Antagonist as Analgesic with Improved Acute and Chronic Side Effects
Proceedings of the 35th European Peptide Symposium·2018· 3 citedOpen Access
Le neuropeptide FF, aiguilleur des macrophages du tissu adipeux
médecine/sciences·2018· 2 citedOpen Access
Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide
Scientific Reports·2017· 90 citedOpen Access
Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages
Journal of Clinical Investigation·2017· 23 citedOpen Access
Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages
Journal of Clinical Investigation·2017· 84 citedOpen Access
RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents
Neuropharmacology·2017· 24 cited
Development of Dipeptidic <i>h</i>GPR54 Agonists
ChemMedChem·2016· 7 cited
Bifunctional Peptide-Based Opioid Agonist–Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain
Journal of Medicinal Chemistry·2016· 48 citedOpen Access
RF-amide neuropeptides and their receptors in Mammals: Pharmacological properties, drug development and main physiological functions
Pharmacology & Therapeutics·2016· 80 cited
Introduction to neuropeptide FF and related RF-amide receptors
Neuropeptides·2016Open Access
Purified full-length GPCRs dose-dependently bind to the central domain of GASP-1 in SPR experiments.
Figshare·2015Open Access
page 1 of 5Next →

Frequent Co-authors

Brigitte L. Kieffer(20), Claire Gavériaux‐Ruff(9), Hans W. D. Matthes(8), Dominique Filliol(7), Gilbert de Murcia(7), Frédéric Bihel(7), Khadija Elhabazi(6), Katia Befort(5), Josiane Ménissier‐de Murcia(5), Brigitte Ilien(5), Raphäelle Quillet(5), Safia Ayachi(5), Rafaël Maldonado(4), Susan Slowe(4), Ian Kitchen(4), Gérard Gradwohl(4), Martine Schmitt(4), Jérôme A. J. Becker(4), Benoit Petit‐Demoulière(4), Valérie Utard(4)