Gilbert de Murcia

University of North Carolina at Chapel Hill — United States

Medicine · Health Sciences

57h-index15.8kcitations133works0.02yr avg
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Research Topics

PARP inhibition in cancer therapy(93), DNA Repair Mechanisms(66), Toxin Mechanisms and Immunotoxins(24), Cancer therapeutics and mechanisms(17), DNA and Nucleic Acid Chemistry(16)

Publications133 total

Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time
UNC Libraries·2020· 6 citedOpen Access
Some Electron Microscopic Aspects of Poly(ADPR) Polymerase-DNA Interactions and of Auto-poly(ADP-ribosyl)ation Reaction
2020
Nucleosomal Poly(ADP-ribose) Polymerase: Properties and Relaxation of the Chromatin Structure
2020· 8 cited
Poly(ADP-ribose) polymerase 2 contributes to neuroinflammation and neurological dysfunction in mouse experimental autoimmune encephalomyelitis
Journal of Neuroinflammation·2013· 30 citedOpen Access
Radiation-induced mitotic catastrophe in PARG-deficient cells
Journal of Cell Science·2009· 128 cited
XRCC1 interacts with the p58 subunit of DNA Pol α-primase and may coordinate DNA repair and replication during S phase
Nucleic Acids Research·2009· 28 citedOpen Access
PARP-1 is involved in autophagy induced by DNA damage
Autophagy·2009· 233 citedOpen Access
Poly(ADP-ribose) polymerase-2 controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-γ heterodimer (Journal of Biological Chemistry (2007) 282, (37738-37746))
Journal of Biological Chemistry·2008· 5 cited
Poly(ADP-ribose) polymerase-2 controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-γ heterodimer. VOLUME 282 (2007) PAGES 37738-37746
Journal of Biological Chemistry·2008Open Access
Peroxisome Proliferator-activated Receptor (PPAR)-2 Controls Adipocyte Differentiation and Adipose Tissue Function through the Regulation of the Activity of the Retinoid X Receptor/PPARγ Heterodimer
Journal of Biological Chemistry·2007· 103 citedOpen Access
Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition
BMC Molecular Biology·2007· 171 citedOpen Access
A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance
Cell Death and Differentiation·2007· 15 cited
Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis
Proceedings of the National Academy of Sciences·2006· 124 citedOpen Access
PARP‐2 deficiency affects the survival of CD4+CD8+ double‐positive thymocytes
The EMBO Journal·2006· 127 citedOpen Access
Poly(ADP-ribose): novel functions for an old molecule
Nature Reviews Molecular Cell Biology·2006· 1.9k cited
Control of AIF-mediated Cell Death by the Functional Interplay of SIRT1 and PARP-1 in Response to DNA Damage
Cell Cycle·2006· 194 citedOpen Access
Parp‐1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells
The EMBO Journal·2006· 268 citedOpen Access
Poly(ADP‐ribose) Polymerase–1 Activation During DNA Damage and Repair
Methods in enzymology on CD-ROM/Methods in enzymology·2006· 163 cited
Control of AIF-mediated Cell Death by the Functional Interplay of SIRT1 and PARP-1 in Response to DNA Damage .
HAL (Le Centre pour la Communication Scientifique Directe)·2006· 17 cited
PARP-2: Structure-Function Relationship
2006· 17 cited
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Frequent Co-authors

Josiane Ménissier‐de Murcia(20), Valérie Schreiber(13), Josiane Ménissier de Murcia(6), F. Javier Oliver(6), Guy G. Poirier(6), Françoise Dantzer(5), Jean‐Christophe Amé(5), Sylviane Muller(4), M. Molinete(4), Ann Huletsky(4), Manuel Mark(3), Gérard Gradwohl(3), Frédéric Simonin(3), José Antonio Muñoz‐Gámez(3), Rocío Aguilar‐Quesada(3), David Martín‐Oliva(3), Aline Huber(3), Daniel Lamarre(3), Paolo Sassone‐Corsi(3), Catherine Spenlehauer(2)