James R. Whittle

Walter and Eliza Hall Institute of Medical Research — Australia

Medicine · Health Sciences

17h-index2.0kcitations104works4.72yr avg
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Research Topics

Glioma Diagnosis and Treatment(28), Advanced Breast Cancer Therapies(21), Cancer Genomics and Diagnostics(12), Single-cell and spatial transcriptomics(12), HER2/EGFR in Cancer Research(10)

Publications104 total

Abstract PS1-10-07: Progression free survival and exploratory endpoints from PALVEN: a phase 1b study of palbociclib, letrozole and venetoclax in ER and BCL2-positive metastatic breast cancer
Clinical Cancer Research·2026
An integrative spatial multi-omic workflow for unified analysis of tumor tissue
Cell Reports Methods·2026Open Access
Patient-derived organoids and neurospheres recapitulate salient features of primary tumor heterogeneity
Neuro-Oncology Advances·2025Open Access
EPCO-27. SMINT AND SPAMTP: INTEGRATIVE SPATIAL ANALYSIS TOOLS REVEAL METABOLIC AND TRANSCRIPTIONAL DRIVERS OF INVASION IN IDH-MUTATED GLIOMA
Neuro-Oncology·2025Open Access
TIP-16. Low and Intermediate Grade Glioma Umbrella Study of Molecular Guided TherapieS (LUMOS2) study
Neuro-Oncology·2025Open Access
A new genetically engineered transplant model of glioma recapitulates key phenotypes of low- and high-grade gliomas
2025Open Access
P01.06.B THERAPEUTIC REPURPOSING REVEALS NOVEL INTERVENTIONS FOR HETEROGENEOUS GLIOBLASTOMA
Neuro-Oncology·2025Open Access
Perioperative IDH inhibition in treatment-naive IDH-mutant glioma: a pilot trial
Nature Medicine·2025· 3 citedOpen Access
Abstract P2-07-18: Results from PALVEN: A Phase 1b Study of Palbociclib, Letrozole and Venetoclax in ER and BCL2-Positive Metastatic Breast Cancer
Clinical Cancer Research·2025
Efficacy and safety of selumetinib in adults with neurofibromatosis type 1 and symptomatic, inoperable plexiform neurofibromas (KOMET): a multicentre, international, randomised, placebo-controlled, parallel, double-blind, phase 3 study
The Lancet·2025· 13 cited
Efficacy and safety of selumetinib in adults with neurofibromatosis type 1 (NF1) and symptomatic, inoperable plexiform neurofibroma (PN): Primary analysis of KOMET (NCT04924608), a phase 3, international, randomized, placebo-controlled study.
Journal of Clinical Oncology·2025
Residual Disease as a Decider
International Journal of Radiation Oncology*Biology*Physics·2025Open Access
TIRE-seq simplifies transcriptomics via integrated RNA capture and library preparation
Scientific Reports·2025· 1 citedOpen Access
To framework, or not to framework? Reflections from co-design of a digital supportive care platform for patients with brain tumours and their carers
Digital Health·2025Open Access
Co-Designing a User-Centered Digital Health Tool for Supportive Care Needs of Patients With Brain Tumors and Their Caregivers: Interview Analysis
JMIR Cancer·2025· 2 citedOpen Access
Three-dimensional patient-derived models of glioblastoma retain intra-tumoral heterogeneity
2025· 2 citedOpen Access
Spatial omics shed light on the tumour organisation of glioblastoma
Seminars in Cell and Developmental Biology·2025· 5 citedOpen Access
IDH-mutant gliomas in children and adolescents - from biology to clinical trials
Frontiers in Oncology·2025· 4 citedOpen Access
Development of an evidence-informed implementation strategy for a digital supportive care platform for brain tumour patients, their carers and healthcare professionals
Digital Health·2025· 2 citedOpen Access
First-in-human study of an EGFRvIII x CD3 T cell bispecific antibody in the treatment of newly diagnosed glioblastoma
Neuro-Oncology Advances·2025Open Access
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Frequent Co-authors

Sarah A. Best(14), Saskia Freytag(13), Geoffrey J. Lindeman(11), Jane E. Visvader(11), François Vaillant(8), Mark Rosenthal(7), Vinod K. Narayana(6), Gordon K. Smyth(5), Jayesh Desai(5), Joel J D Moffet(5), Lutz Freytag(5), Jordan Jones(5), Zachery Moore(5), Katharine J. Drummond(5), Tianyao Lu(5), Marco J. Herold(4), Sarah‐Jane Dawson(4), Elliot Surgenor(4), Jurgen Kriel(4), Andrew Morokoff(4)