Ingrid A. Stock

National Institute on Drug Abuse — United States

Neuroscience · Life Sciences

18h-index1.1kcitations29works0.02yr avg
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Research Topics

Regulation of Appetite and Obesity(6), Receptor Mechanisms and Signaling(6), Biochemical Analysis and Sensing Techniques(5), Protein Degradation and Inhibitors(5), Pancreatic function and diabetes(4)

Publications29 total

Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3
Bioorganic & Medicinal Chemistry Letters·2023· 7 citedOpen Access
Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life
ACS Medicinal Chemistry Letters·2023· 3 citedOpen Access
Initial Pharmacological Characterization of a Major Hydroxy Metabolite of PF-5190457: Inverse Agonist Activity of PF-6870961 at the Ghrelin Receptor
Journal of Pharmacology and Experimental Therapeutics·2023· 6 citedOpen Access
Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4
Journal of Medicinal Chemistry·2022· 19 citedOpen Access
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis
Journal of Medicinal Chemistry·2022· 25 cited
CCDC 2098502: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose
Journal of Medicinal Chemistry·2020· 69 citedOpen Access
Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain
Journal of Medicinal Chemistry·2017· 40 citedOpen Access
Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor
Journal of the American Chemical Society·2017· 108 citedOpen Access
Small molecule and peptidic ligands as PCSK9-LDLR inhibitors
Queensland's institutional digital repository (The University of Queensland)·2017
CCDC 1566743: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
Pharmacological characterization of the first in class clinical candidate PF‐05190457: a selective ghrelin receptor competitive antagonist with inverse agonism that increases vagal afferent firing and glucose‐dependent insulin secretion<i>ex vivo</i>
British Journal of Pharmacology·2016· 26 citedOpen Access
Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities
Chemistry & Biology·2015· 60 citedOpen Access
Direct photocapture of bromodomains using tropolone chemical probes
MedChemComm·2015· 11 cited
Evaluation and Synthesis of Polar Aryl- and Heteroaryl Spiroazetidine-Piperidine Acetamides as Ghrelin Inverse Agonists
ACS Medicinal Chemistry Letters·2014· 19 citedOpen Access
Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate
ACS Medicinal Chemistry Letters·2014· 67 citedOpen Access
Design and Synthesis of Truncated EGF-A Peptides that Restore LDL-R Recycling in the Presence of PCSK9 In Vitro
Chemistry & Biology·2014· 72 cited
Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor
Bioorganic & Medicinal Chemistry Letters·2013· 27 citedOpen Access
CCDC 948624: Experimental Crystal Structure Determination
The Cambridge Structural Database·2013Open Access
Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor
Bioorganic & Medicinal Chemistry Letters·2012· 26 citedOpen Access
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Frequent Co-authors

Meihua Tu(8), Kim F. McClure(8), Shenping Liu(7), Samit K. Bhattacharya(7), William H. Martin(6), Robert Dullea(6), Steven B. Coffey(6), Dilinie P. Fernando(6), Kimberly Lapham(6), Paula M. Loria(6), Benjamin A. Thuma(5), Mark Ammirati(5), Matthew Dowling(5), Kimberly O. Cameron(5), Parag V. Sahasrabudhe(5), Ronald P. Gladue(4), Laurie Tylaska(4), John C. Kath(4), Amy P DiRico(4), Eric B. McElroy(4)