Meihua Tu

Pfizer (United States) — United States

Medicine · Health Sciences

27h-index2.9kcitations68works0.02yr avg
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Research Topics

Pancreatic function and diabetes(13), Computational Drug Discovery Methods(12), Diabetes Treatment and Management(9), Metabolism, Diabetes, and Cancer(8), Protein Structure and Dynamics(7)

Publications68 total

Small molecule inhibitors of PCSK9. SAR investigations of head and amine groups
Bioorganic & Medicinal Chemistry Letters·2023· 2 citedOpen Access
Quantum Mechanics Modeling of Oxetanes as Epoxide Hydrolase Substrates
Letters in Drug Design & Discovery·2022
Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate
Nature Structural & Molecular Biology·2022· 48 citedOpen Access
TorsionNet: A Deep Neural Network to Rapidly Predict Small-Molecule Torsional Energy Profiles with the Accuracy of Quantum Mechanics
Journal of Chemical Information and Modeling·2022· 44 cited
Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate
2021· 6 citedOpen Access
CCDC 2098502: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
TorsionNet: A Deep Neural Network to Rapidly Predict Small Molecule Torsion Energy Profiles with the Accuracy of Quantum Mechanics
2020Open Access
TorsionNet: A Deep Neural Network to Rapidly Predict Small Molecule Torsion Energy Profiles with the Accuracy of Quantum Mechanics
2020· 5 citedOpen Access
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose
Journal of Medicinal Chemistry·2020· 69 citedOpen Access
Generative Network Complex for the Automated Generation of Drug-like Molecules
Journal of Chemical Information and Modeling·2020· 116 citedOpen Access
Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease
Journal of Lipid Research·2020· 15 citedOpen Access
Generative network complex for the automated generation of druglike molecules
arXiv (Cornell University)·2020· 1 citedOpen Access
Are 2D fingerprints still valuable for drug discovery?
Physical Chemistry Chemical Physics·2020· 135 citedOpen Access
Comprehensive Assessment of Torsional Strain in Crystal Structures of Small Molecules and Protein–Ligand Complexes using ab Initio Calculations
Journal of Chemical Information and Modeling·2019· 52 cited
Sports Related Fitness Evaluation and High Intensity Interval Training in Table Tennis Players
Medicine & Science in Sports & Exercise·2018· 2 cited
Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing
Journal of the American Chemical Society·2018· 152 citedOpen Access
Receptor‐Mediated Delivery of CRISPR‐Cas9 Endonuclease for Cell Type Specific Gene Editing
The FASEB Journal·2018Open Access
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK)
Journal of Medicinal Chemistry·2018· 17 citedOpen Access
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)
Journal of Medicinal Chemistry·2017· 49 citedOpen Access
Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor
Xenobiotica·2017· 10 cited
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Frequent Co-authors

Jeffrey A. Pfefferkorn(14), John Litchfield(12), Kevin J. Filipski(11), Spiros Liras(10), Angel Guzmán-Pérez(10), Karen Atkinson(10), Alan M. Mathiowetz(7), Francis Rajamohan(7), Allan R. Reyes(7), Gary E. Aspnes(7), Jianwei Bian(7), Kris A. Borzilleri(6), Amit S. Kalgutkar(6), Shenping Liu(6), Mary T. Didiuk(6), Benjamin A. Thuma(5), Christopher T. Salatto(5), Jessica Ward(5), Jane M. Withka(5), Janice A. Brown(5)