Jeffrey A. Pfefferkorn

Pfizer (United States) — United States

Medicine · Health Sciences

44h-index5.2kcitations116works0.02yr avg
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Research Topics

Pancreatic function and diabetes(22), Synthetic Organic Chemistry Methods(17), Lipoproteins and Cardiovascular Health(16), Metabolism, Diabetes, and Cancer(16), Marine Sponges and Natural Products(16)

Publications116 total

Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis
Journal of Medicinal Chemistry·2022· 25 cited
ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials
Nature Medicine·2021· 207 cited
CCDC 2098502: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction
Molecular Metabolism·2021· 80 citedOpen Access
De novo lipogenesis is essential for platelet production in humans
Nature Metabolism·2020· 47 cited
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose
Journal of Medicinal Chemistry·2020· 69 citedOpen Access
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
Journal of Medicinal Chemistry·2020· 29 cited
Quantitation of Urinary Acylcarnitines by DMS-MS/MS Uncovers the Effects of Total Body Irradiation in Cancer Patients
Journal of the American Society for Mass Spectrometry·2020· 7 citedOpen Access
Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems
Cellular and Molecular Gastroenterology and Hepatology·2020· 89 citedOpen Access
Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition
Science Translational Medicine·2019· 62 cited
PS-132-The acetyl-CoA carboxylase inhibitor PF-05221304 exerts direct effects on hepatic inflammation and fibrosis independent of benefits on steatosis
Journal of Hepatology·2019· 3 cited
PS-109-Partial inhibition of de novo lipogenesis with the acetyl-CoA carboxylase inhibitor PF-05221304 does not increase circulating triglycerides in humans and is sufficient to lower steatosis in rats
Journal of Hepatology·2019· 2 cited
Effect of Hepatic Organic Anion‐Transporting Polypeptide 1B Inhibition and Chronic Kidney Disease on the Pharmacokinetics of a Liver‐Targeted Glucokinase Activator: A Model‐Based Evaluation
Clinical Pharmacology & Therapeutics·2019· 23 cited
Differential mobility spectrometry (DMS) reveals the elevation of urinary acetylcarnitine in non‐human primates (NHPs) exposed to radiation
Journal of Mass Spectrometry·2018· 15 citedOpen Access
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)
Journal of Medicinal Chemistry·2017· 49 citedOpen Access
Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells
PLoS ONE·2017· 111 citedOpen Access
Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism
ACS Chemical Biology·2016· 21 citedOpen Access
Impact of Mitochondrial Uncoupling on Hepatic Metabolism and Novel Human Hepatic System for Type 2 Diabetes
Journal of Hepatology·2016
Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)
Scientific Reports·2015· 68 citedOpen Access
Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)
Journal of Medicinal Chemistry·2015· 80 cited
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Frequent Co-authors

K. C. Nicolaou(12), Sanghee Kim(9), Meihua Tu(8), Guoqiang Cao(7), Sofía Barluenga(7), Takashi Ohshima(7), Trenton T. Ross(6), William P. Esler(6), K. C. Nicolaou(6), Dionisios Vourloumis(6), Jinyou Xu(6), John Litchfield(6), Kevin J. Filipski(6), Gary E. Aspnes(6), Seijiro Hosokawa(6), Nicholas B. Vera(6), Chulho Choi(6), Melissa S. Harris(6), Jianwei Bian(5), John D. Knafels(5)