Melissa S. Harris

Pfizer (United States) — United States

Computer Science · Physical Sciences

18h-index3.2kcitations30works0.02yr avg
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Research Topics

Computational Drug Discovery Methods(5), Biochemical and Molecular Research(5), Hepatitis C virus research(4), Lipoproteins and Cardiovascular Health(4), Enzyme Structure and Function(4)

Publications30 total

Driving Drug Discovery with Biophysical Information
2017· 2 cited
Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms
Structure·2014· 179 citedOpen Access
Activation of AMP-Activated Protein Kinase Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry
Structure·2013· 39 citedOpen Access
The Solution Structure of Monomeric Hepatitis C Virus p7 Yields Potent Inhibitors of Virion Release
2012
Outlet Density as a Predictor of Alcohol Use in Early Adolescence
Substance Use & Misuse·2011· 9 cited
Community reinsertion success of street children programs in Brazil and Peru
Children and Youth Services Review·2010· 30 cited
Discovering Expectant Mothers' Beliefs about Oral Health: An Application of the Centering Pregnancy Smiles® Program
International Quarterly of Community Health Education·2010· 19 cited
Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics·2010· 67 cited
Escherichia coli expression, purification and characterization of functional full-length recombinant α2β2γ3 heterotrimeric complex of human AMP-activated protein kinase
Protein Expression and Purification·2010· 28 cited
A Short-Term, Quasi-Experimental Evaluation of D.A.R.E.'s Revised Elementary School Curriculum
Journal of Drug Education·2010· 65 cited
Caspase 8 with covalent inhibitor
2009
Caspase 3 Bound to a covalent inhibitor
2009
Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain
Protein Expression and Purification·2009· 20 cited
Structural comparison of chromosomal and exogenous dihydrofolate reductase from <i>Staphylococcus aureus</i> in complex with the potent inhibitor trimethoprim
Proteins Structure Function and Bioinformatics·2009· 132 cited
Thermodynamic and Structure Guided Design of Statin Based Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase
Journal of Medicinal Chemistry·2008· 64 citedOpen Access
Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors
2008
Substituted Pyrazoles as Hepatoselective HMG-CoA Reductase Inhibitors: Discovery of (3<i>R</i>,5<i>R</i>)-7-[2-(4-Fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2<i>H</i>-pyrazol-3-yl]-3,5-dihydroxyheptanoic Acid (PF-3052334) as a Candidate for the Treatment of Hypercholesterolemia
Journal of Medicinal Chemistry·2007· 58 citedOpen Access
Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors
2007
Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors
Bioorganic & Medicinal Chemistry Letters·2007· 55 citedOpen Access
Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors
Bioorganic & Medicinal Chemistry Letters·2007· 40 citedOpen Access
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Frequent Co-authors

Jeffrey A. Pfefferkorn(7), B.C. Finzel(7), A.G. Pavlovsky(6), Eric T. Baldwin(6), Nicole Caspers(5), Ronald W. Sarver(4), Alfredo G. Tomasselli(4), Scott D. Larsen(4), Graeme Bainbridge(4), Gil H. Choi(4), J. I. CIALDELLA(4), Francis Rajamohan(3), Lise R. Hoth(3), Ravi G. Kurumbail(3), William Watt(3), James R. Blinn(3), Satwik Kamtekar(3), Timothy E. Benson(3), John T. Herberg(3), Chulho Choi(3)