Satwik Kamtekar

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index3.6kcitations53works0.02yr avg
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Research Topics

RNA and protein synthesis mechanisms(10), DNA Repair Mechanisms(8), Bacterial Genetics and Biotechnology(7), DNA and Nucleic Acid Chemistry(7), RNA modifications and cancer(7)

Publications53 total

Structure of a Synaptic γδ Resolvase Tetramer Covalently Linked to Two Cleaved DNAs
WORLD SCIENTIFIC eBooks·2020
Phi29 DNA polymerase: structure and sequencing
Acta Crystallographica Section A Foundations and Advances·2019Open Access
Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design
Journal of Medicinal Chemistry·2017· 138 citedOpen Access
CCDC 1566948: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
Protein Design byBinary Patterning ofPolar andNonpolar Amino Acids
2017
CCDC 1566947: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1566949: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1566946: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
Crystal structure of an intermediate of rotating dimers within the synaptic tetramer of the G-segment invertase
Nucleic Acids Research·2012· 31 citedOpen Access
Crystal Structure of the synaptic tetramer of the G-Segment Invertase (Gin)
2011
Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain
Bioorganic & Medicinal Chemistry Letters·2011· 31 cited
Structural basis of substrate discrimination and integrin binding by autotaxin
Nature Structural & Molecular Biology·2011· 279 citedOpen Access
Crystallization and preliminary X-ray diffraction analysis of rat autotaxin
Acta Crystallographica Section F Structural Biology and Crystallization Communications·2010· 11 citedOpen Access
Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics·2010· 67 cited
Crystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme Inactivation
Journal of Molecular Biology·2010· 105 citedOpen Access
3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with Carbamate inhibitor URB597
2010
Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode
Bioorganic & Medicinal Chemistry Letters·2010· 35 citedOpen Access
Caspase 8 with covalent inhibitor
2009
Caspase 3 Bound to a covalent inhibitor
2009
Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis
Nature Structural & Molecular Biology·2009· 91 citedOpen Access
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Frequent Co-authors

Thomas A. Steitz(19), Andrea J. Berman(10), José M. Lázaro(9), Miguel de Vega(9), Jacqueline E. Day(8), Mauro Mileni(6), Raymond C. Stevens(6), Betsy S. Pierce(6), Michael H. Hecht(5), Luis Blanco(5), Margarita Salas(5), Katherine L. Lee(5), Catherine M. Ambler(5), Brian P. Boscoe(5), Andrea G. Bree(5), Joanne Brodfuehrer(5), Jeanne S. Chang(5), Chulho Choi(5), Kevin J. Curran(5), Christoph M. Dehnhardt(5)