José M. Lázaro

Consejo Superior de Investigaciones Científicas — Spain

Biochemistry, Genetics and Molecular Biology · Life Sciences

29h-index3.4kcitations83works0.02yr avg
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Research Topics

DNA Repair Mechanisms(44), Bacterial Genetics and Biotechnology(40), DNA and Nucleic Acid Chemistry(38), Bacteriophages and microbial interactions(35), RNA and protein synthesis mechanisms(17)

Publications83 total

The Loop of the TPR1 Subdomain of Phi29 DNA Polymerase Plays a Pivotal Role in Primer-Terminus Stabilization at the Polymerization Active Site
Biomolecules·2019· 2 citedOpen Access
New insights into the coordination between the polymerization and 3′-5′ exonuclease activities in ϕ29 DNA polymerase
Scientific Reports·2019· 15 citedOpen Access
Improvement of ϕ29 DNA Polymerase Amplification Performance by Fusion of DNA Binding Motifs
2016· 3 cited
Insights into the Determination of the Templating Nucleotide at the Initiation of φ29 DNA Replication
Journal of Biological Chemistry·2015· 7 citedOpen Access
Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase
Nucleic Acids Research·2015· 60 citedOpen Access
Kinetic Mechanisms Governing Stable Ribonucleotide Incorporation in Individual DNA Polymerase Complexes
Biochemistry·2014· 6 cited
Dynamics of Translocation and Substrate Binding in Individual Complexes Formed with Active Site Mutants of Φ29 DNA Polymerase
Journal of Biological Chemistry·2014· 6 citedOpen Access
Identification of the Translocation Step of a Replicative DNA Polymerase
Biophysical Journal·2014Open Access
Role of the LEXE Motif of Protein-primed DNA Polymerases in the Interaction with the Incoming Nucleotide
Journal of Biological Chemistry·2013· 6 citedOpen Access
Dual Role of φ29 DNA Polymerase Lys529 in Stabilisation of the DNA Priming-Terminus and the Terminal Protein-Priming Residue at the Polymerisation Site
PLoS ONE·2013· 5 citedOpen Access
Crystal structure and functional insights into uracil-DNA glycosylase inhibition by phage ϕ29 DNA mimic protein p56
Nucleic Acids Research·2013· 25 citedOpen Access
Active DNA unwinding dynamics during processive DNA replication
Proceedings of the National Academy of Sciences·2012· 77 citedOpen Access
Novel dimeric structure of phage ϕ29-encoded protein p56: insights into uracil-DNA glycosylase inhibition
Nucleic Acids Research·2011· 19 citedOpen Access
Characterization of<i>Bacillus subtilis</i>uracil‐DNA glycosylase and its inhibition by phage φ29 protein p56
Molecular Microbiology·2011· 14 cited
Improvement of φ29 DNA polymerase amplification performance by fusion of DNA binding motifs
Proceedings of the National Academy of Sciences·2010· 70 citedOpen Access
ϕ29 DNA Polymerase Active Site: Role of Residue Val250 as Metal–dNTP Complex Ligand and in Protein-Primed Initiation
Journal of Molecular Biology·2009· 4 citedOpen Access
Proofreading dynamics of a processive DNA polymerase
The EMBO Journal·2009· 109 citedOpen Access
Functional Importance of Bacteriophage ϕ29 DNA Polymerase Residue Tyr148 in Primer-terminus Stabilisation at the 3′-5′ Exonuclease Active Site
Journal of Molecular Biology·2009· 7 citedOpen Access
Involvement of the TPR2 subdomain movement in the activities of  29 DNA polymerase
Nucleic Acids Research·2008· 9 citedOpen Access
Phage φ29 and Nf terminal protein-priming domain specifies the internal template nucleotide to initiate DNA replication
Proceedings of the National Academy of Sciences·2008· 12 citedOpen Access
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Frequent Co-authors

Margarita Salas(39), Luis Blanco(23), Miguel de Vega(19), António Bernad(7), M. Salas(7), Marı́a A. Blasco(7), L. Blanco(6), Laurentino Villar(6), José M. Hermoso(5), Satwik Kamtekar(4), Andrea J. Berman(4), Thomas A. Steitz(4), Irene Rodrı́guez(4), Borja Ibarra(3), Juan Méndez(3), Julio Gutiérrez(3), Isabel Prieto(3), Manuel Serrano(3), Gemma Serrano‐Heras(3), Elisa Longás(3)