L. Blanco

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index955citations24works0.02yr avg
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Research Topics

DNA Repair Mechanisms(12), DNA and Nucleic Acid Chemistry(8), Bacterial Genetics and Biotechnology(6), Bacteriophages and microbial interactions(6), RNA and protein synthesis mechanisms(5)

Publications24 total

CCDC 858773: Experimental Crystal Structure Determination
The Cambridge Structural Database·2013Open Access
CCDC 756013: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
CCDC 756014: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
Phi29 DNA polymerase complexed with primer-template DNA and incoming nucleotide substrates (ternary complex)
2007
Phi29 DNA polymerase complexed with single-stranded DNA
2007
Crystal Structure of human DNA Polymerase lambda with a G/G mismatch in the primer terminus
2006
Bacteriophage phi29 DNA polymerase bound to terminal protein
2005
Phi29 DNA polymerase ssDNA complex, monoclinic crystal form
2004
Phi29 DNA polymerase, orthorhombic crystal form, ssDNA complex
2004
Crystal structure of DNA polymerase lambda complexed with a two nucleotide gap DNA molecule
2003
Processive proofreading by the adenovirus DNA polymerase. Association with the priming protein reduces exonucleolytic degradation
Nucleic Acids Research·1997· 25 citedOpen Access
[5] Purification of bacteriophage φ29 DNA polymerase
Methods in enzymology on CD-ROM/Methods in enzymology·1995· 82 cited
Phi 29 DNA polymerase active site. Residue ASP249 of conserved amino acid motif “Dx2SLYP” is critical for synthetic activities.
Journal of Biological Chemistry·1993· 47 citedOpen Access
Phi 29 DNA polymerase active site. The conserved amino acid motif “Kx3NSxYG” is involved in template-primer binding and dNTP selection
Journal of Biological Chemistry·1993· 52 citedOpen Access
Fidelity of phi 29 DNA polymerase. Comparison between protein-primed initiation and DNA polymerization.
Journal of Biological Chemistry·1993· 285 citedOpen Access
Phi 29 DNA polymerase active site. Mutants in conserved residues Tyr254 and Tyr390 are affected in dNTP binding.
Journal of Biological Chemistry·1992· 56 citedOpen Access
MIP1 DNA polymerase of S.<i>cerevisiae</i>: structural similarity with the<i>E.coli</i>DNA polymerase I-type enzymes
Nucleic Acids Research·1991· 22 citedOpen Access
Structural and functional analysis of temperature-sensitive mutants of the phage phi 29 DNA polymerase.
PubMed·1990· 32 citedOpen Access
Characterization of the 3 5 exonuclease active site in the phi 29 dna polymerase
1989
Protein-primed replication of bacteriophage Φ29 DNA
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression·1988· 11 cited
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Frequent Co-authors

M. Salas(10), José M. Lázaro(10), António Bernad(6), Margarita Salas(5), Marı́a A. Blasco(5), Satwik Kamtekar(5), Andrea J. Berman(5), Miguel de Vega(5), Thomas A. Steitz(5), María Salas(4), R. Guillot(3), Sandrine Deloisy(3), J. Wang(3), Julio Gutiérrez(2), José M. Hermoso(2), Eulalia Pares(2), Adrien Soret(2), C. Müller(2), Miguel Garcı́a-Dı́az(2), Katarzyna Bębenek(2)