Joanne Brodfuehrer

Hudson Institute — United States

Medicine · Health Sciences

19h-index1.6kcitations49works0.02yr avg
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Research Topics

Drug Transport and Resistance Mechanisms(10), Pharmacogenetics and Drug Metabolism(9), Computational Drug Discovery Methods(6), HIV Research and Treatment(4), HIV/AIDS drug development and treatment(4)

Publications49 total

Issue Information
Clinical Pharmacology in Drug Development·2022Open Access
A Phase 1 Study to Assess Mass Balance and Absolute Bioavailability of Zimlovisertib in Healthy Male Participants Using a <sup>14</sup>C‐Microtracer Approach
Clinical Pharmacology in Drug Development·2022· 8 citedOpen Access
Dystrophin and mini-dystrophin quantification by mass spectrometry in skeletal muscle for gene therapy development in Duchenne muscular dystrophy
Gene Therapy·2021· 29 citedOpen Access
DMD - BIOMARKERS
Neuromuscular Disorders·2021
The Interleukin‐1 Receptor–Associated Kinase 4 Inhibitor PF‐06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial
Arthritis & Rheumatology·2021· 86 citedOpen Access
Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors
European Journal of Medicinal Chemistry·2017· 24 citedOpen Access
Biomeasures and mechanistic modeling highlight PK/PD risks for a monoclonal antibody targeting Fn14 in kidney disease
mAbs·2017· 4 citedOpen Access
Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design
Journal of Medicinal Chemistry·2017· 138 citedOpen Access
CCDC 1566948: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1566947: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1566949: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1566946: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
Quantitative Analysis of Target Coverage and Germinal Center Response by a CXCL13 Neutralizing Antibody in a T-Dependent Mouse Immunization Model
Pharmaceutical Research·2013· 20 cited
Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Rat Prefrontal Cortical Dopamine Response to Dual Acting Norepinephrine Reuptake Inhibitor and 5-HT1A Partial Agonist
The AAPS Journal·2012· 6 citedOpen Access
Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rats, Dogs, and Humans
2011· 7 cited
Current Advances in Delivery of Biotherapeutics Across the Blood-Brain Barrier
Current Drug Discovery Technologies·2011· 47 cited
Understanding the clinical pharmacokinetics of a GABA<sub>A</sub>partial agonist by application of<i>in vitro</i>tools
Xenobiotica·2010· 6 cited
Assessment of the renal toxicity of novel anti-inflammatory compounds using cynomolgus monkey and human kidney cells
Toxicology·2009· 20 cited
The Use of 1-Aminobenzotriazole in Differentiating the Role of CYPMediated First Pass Metabolism and Absorption in Limiting Drug Oral Bioavailability: A Case Study
Drug Metabolism Letters·2008· 16 cited
Antibacterial Oxazolidinones Possessing a Novel C-5 Side Chain. (5<i>R</i>)-<i>trans</i>-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic Acid Amide (PF-00422602), a New Lead Compound
Journal of Medicinal Chemistry·2007· 28 citedOpen Access
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Frequent Co-authors

Jeanne S. Chang(6), Ken Dower(6), Richard K. Frisbie(6), Martin Hegen(6), David Hepworth(6), Iain Kilty(6), Frank Lovering(6), Nikolaos Papaioannou(6), Vikram R. Rao(6), Joseph W. Strohbach(6), Peter T. Symanowicz(6), Fabien Vincent(6), Christoph W. Zapf(6), Lih‐Ling Lin(6), Katherine L. Lee(5), Catherine M. Ambler(5), Brian P. Boscoe(5), Andrea G. Bree(5), Chulho Choi(5), Kevin J. Curran(5)