Peter T. Symanowicz

Pfizer (United States) — United States

Medicine · Health Sciences

13h-index1.2kcitations21works0.02yr avg
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Research Topics

Cytokine Signaling Pathways and Interactions(9), Rheumatoid Arthritis Research and Therapies(6), Systemic Lupus Erythematosus Research(4), Crystallization and Solubility Studies(4), X-ray Diffraction in Crystallography(4)

Publications21 total

Predicting kinase target inhibition level for efficacy in rheumatoid arthritis: A translational approach based on collagen-induced arthritis rodent studies
Journal of Pharmacology and Experimental Therapeutics·2025
RORγt inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating γδ-T cells
Lara D. Veeken·2023· 24 citedOpen Access
The Interleukin‐1 Receptor–Associated Kinase 4 Inhibitor PF‐06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial
Arthritis & Rheumatology·2021· 86 citedOpen Access
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( <i>S</i> )-2,2-Difluorocyclopropyl)((1 <i>R</i> ,5 <i>S</i> )-3-(2-((1-methyl-1 <i>H</i> -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)
Journal of Medicinal Chemistry·2018· 166 citedOpen Access
Identification of <i>N</i>-{<i>cis</i>-3-[Methyl(7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases
Journal of Medicinal Chemistry·2018· 162 citedOpen Access
Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design
Journal of Medicinal Chemistry·2017· 138 citedOpen Access
CCDC 1566948: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1566947: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1566949: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1566946: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition
ACS Chemical Biology·2016· 187 citedOpen Access
Network pharmacology of JAK inhibitors
Proceedings of the National Academy of Sciences·2016· 64 citedOpen Access
OP0155 Development of A JAK3 Specific Inhibitor Clinical Candidate: Functional Differentiation of JAK3 Selective Inhibition over PAN-JAK or JAK1 Selective Inhibition
Annals of the Rheumatic Diseases·2016
JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production
Arthritis & Rheumatism·2012· 130 cited
Selective functional inhibition of JAK‐3 is sufficient for efficacy in collagen‐induced arthritis in mice
Arthritis & Rheumatism·2010· 74 cited
The novel and selective JAK3 inhibitor WYE-152038 is highly efficacious in a mouse model of rheumatoid arthritis
Cytokine·2009
Lack of role for the vanilloid receptor in response to several inspired irritant air pollutants in the C57Bl/6J mouse
Neuroscience Letters·2004· 46 cited
Immediate sensory nerve-mediated respiratory responses to irritants in healthy and allergic airway-diseased mice
Journal of Applied Physiology·2003· 66 cited
EFFECT OF NITROGEN DIOXIDE ON OVALBUMIN-INDUCED ALLERGIC AIRWAY DISEASE IN A MURINE MODEL
Journal of Toxicology and Environmental Health·2002· 10 cited
Regional distribution and kinetics of vinyl acetate hydrolysis in the oral cavity of the rat and mouse
Toxicology Letters·2002· 18 cited
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Frequent Co-authors

Martin Hegen(15), Fabien Vincent(8), Catherine M. Ambler(7), Tsung H. Lin(6), James D. Clark(6), Betsy S. Pierce(6), Eddine Saiah(6), Joseph W. Strohbach(6), John D. Trzupek(6), Seungil Han(6), Joanne Brodfuehrer(6), Ken Dower(6), Iain Kilty(6), Vikram R. Rao(6), Jean‐Baptiste Telliez(5), Katherine L. Lee(5), Brian P. Boscoe(5), Andrea G. Bree(5), Jeanne S. Chang(5), Chulho Choi(5)