John D. Trzupek

Pfizer (United States) — United States

Materials Science · Physical Sciences

18h-index1.5kcitations38works0.02yr avg
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Research Topics

Crystallization and Solubility Studies(12), X-ray Diffraction in Crystallography(12), Cancer therapeutics and mechanisms(6), Crystallography and molecular interactions(5), DNA and Nucleic Acid Chemistry(4)

Publications38 total

Discovery of 3-Cyano- <i>N</i> -(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 <i>H</i> -pyrrolo[2,3- <i>b</i> ]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist
Journal of Medicinal Chemistry·2018· 32 citedOpen Access
Identification of <i>N</i>-{<i>cis</i>-3-[Methyl(7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases
Journal of Medicinal Chemistry·2018· 162 citedOpen Access
Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design
Journal of Medicinal Chemistry·2017· 138 citedOpen Access
CCDC 1566948: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1566947: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1566949: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1566946: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit
Journal of Medicinal Chemistry·2016· 107 citedOpen Access
ChemInform Abstract: Reversal of Diastereoselection in the Conjugate Addition of Cuprates to Unsaturated Lactams.
ChemInform·2016
CCDC 1433129: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance
Science Advances·2015· 142 citedOpen Access
Reversal of Diastereoselection in the Conjugate Addition of Cuprates to Unsaturated Lactams
Organic Letters·2015· 26 cited
CCDC 1429567: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
CCDC 1429568: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
CCDC 1429569: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
CCDC 1429565: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
CCDC 1429566: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
CCDC 1429564: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
Epigenetic drugs that do not target enzyme activity
Drug Discovery Today Technologies·2012· 5 cited
Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit
Journal of Medicinal Chemistry·2012· 195 citedOpen Access
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Frequent Co-authors

Chulho Choi(14), Brian P. Boscoe(13), Susan E. Drozda(13), Stephen W. Wright(13), Seungwon Chung(12), Dale L. Boger(9), James J. Mousseau(8), Martin Hegen(7), I. Samardjiev(7), Brian Samas(7), Joseph W. Strohbach(6), Seungil Han(6), Peter T. Symanowicz(6), Christoph W. Zapf(6), Dafydd R. Owen(5), Katherine L. Lee(5), Catherine M. Ambler(5), Andrea G. Bree(5), Joanne Brodfuehrer(5), Jeanne S. Chang(5)