Dionisios Vourloumis

National Centre of Scientific Research "Demokritos" — Greece

Chemistry · Physical Sciences

41h-index5.6kcitations104works0.02yr avg
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Research Topics

Synthetic Organic Chemistry Methods(38), Cancer Treatment and Pharmacology(33), RNA and protein synthesis mechanisms(22), Advanced Synthetic Organic Chemistry(22), Marine Sponges and Natural Products(15)

Publications104 total

Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on α-Hydroxy-β-amino Acid Derivatives of Bestatin
Journal of Medicinal Chemistry·2022· 20 citedOpen Access
Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody–Drug Conjugates, Insights into Structure–Activity Relationships, and Tubulysin–Tubulin Binding Derived from X-ray Crystallographic Analysis
The Journal of Organic Chemistry·2021· 9 cited
CCDC 2011802: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
Streamlined Symmetrical Total Synthesis of Disorazole B<sub>1</sub> and Design, Synthesis, and Biological Investigation of Disorazole Analogues
Journal of the American Chemical Society·2020· 20 cited
Exploration of zinc-binding groups for the design of inhibitors for the oxytocinase subfamily of M1 aminopeptidases
Bioorganic & Medicinal Chemistry·2019· 8 citedOpen Access
Heterometallic In(III)–Pd(II) Porous Metal–Organic Framework with Square-Octahedron Topology Displaying High CO<sub>2</sub> Uptake and Selectivity toward CH<sub>4</sub> and N<sub>2</sub>
Inorganic Chemistry·2018· 42 cited
Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody–Drug Conjugates
Journal of the American Chemical Society·2018· 47 cited
CCDC 1826098: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
CCDC 1826099: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency
ACS Medicinal Chemistry Letters·2017· 23 citedOpen Access
Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins
Journal of the American Chemical Society·2016· 85 cited
CCDC 1482371: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Exceptional gravimetric and volumetric CO<sub>2</sub> uptake in a palladated NbO-type MOF utilizing cooperative acidic and basic, metal–CO<sub>2</sub> interactions
Chemical Communications·2016· 42 cited
Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs
ChemMedChem·2015· 127 cited
3,4-Diaminobenzoic Acid Derivatives as Inhibitors of the Oxytocinase Subfamily of M1 Aminopeptidases with Immune-Regulating Properties
Journal of Medicinal Chemistry·2015· 42 citedOpen Access
CCDC 1421073: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
A Zebrafish <i>In Vivo</i> Phenotypic Assay to Identify 3-Aminothiophene-2-Carboxylic Acid-Based Angiogenesis Inhibitors
Assay and Drug Development Technologies·2014· 17 citedOpen Access
Rigid spiroethers targeting the decoding center of the bacterial ribosome
Bioorganic & Medicinal Chemistry·2014· 7 cited
Synthesis of triazole-functionalized 2-DOS analogues and their evaluation as A-site binders
Bioorganic & Medicinal Chemistry Letters·2014· 6 cited
Novel selective inhibitors of aminopeptidases that generate antigenic peptides
Bioorganic & Medicinal Chemistry Letters·2013· 27 citedOpen Access
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Frequent Co-authors

K. C. Nicolaou(24), Yun He(10), Hans Vallberg(10), Klaus B. Simonsen(10), Benjamin K. Ayida(9), Geoffrey C. Winters(9), Thomas Hermann(9), Nicolas Winssinger(8), Sacha Ninkovic(8), Francisco Sarabia(8), Qiang Zhao(8), Masayuki Takahashi(8), Zhen Yang(7), Frank Roschangar(7), N. Paul King(7), Sarah Shandrick(7), Athanasios Papakyriakou(6), Takashi Ohshima(6), Sanghee Kim(6), Jeffrey A. Pfefferkorn(6)