John Litchfield

Pfizer (United States) — United States

Medicine · Health Sciences

25h-index2.7kcitations59works0.02yr avg
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Research Topics

Drug Transport and Resistance Mechanisms(17), Pancreatic function and diabetes(14), Pharmacogenetics and Drug Metabolism(13), Diabetes Treatment and Management(9), Pharmacological Effects and Toxicity Studies(8)

Publications57 total

Pharmacological inhibition of IRAK4 kinase activity does not prevent cachexia in mice with pancreatic cancer
JCSM Rapid Communications·2023Open Access
Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, a First-In-Class Ketohexokinase Inhibitor for Metabolic Disorders and Nonalcoholic Fatty Liver Disease
Drug Metabolism and Disposition·2022· 7 citedOpen Access
Effect of a Ketohexokinase Inhibitor (PF‐06835919) on <i>In Vivo</i> OATP1B Activity: Integrative Risk Assessment Using Endogenous Biomarker and a Probe Drug
Clinical Pharmacology & Therapeutics·2022· 17 cited
Target occupancy study and whole-body dosimetry with a MAGL PET ligand [11C]PF-06809247 in non-human primates
EJNMMI Research·2022· 6 citedOpen Access
Target Occupancy Study and Whole-Body Dosimetry with a MAGL PET Ligand 11C-PF-06809247 in non-human Primates
Research Square (Research Square)·2021Open Access
Target Occupancy Study and Whole-Body Dosimetry With a MAGL PET Ligand 11C-PF-06809247 in Non-Human Primates
2021Open Access
Organic Anion–Transporting Polypeptide 1B1/1B3–Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro–In Vivo Evaluation in Cynomolgus Monkey
Journal of Pharmacology and Experimental Therapeutics·2021· 19 citedOpen Access
Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs
Journal of Medicinal Chemistry·2020· 25 cited
Discovery of Diphenylacetamides as CXCR7 Inhibitors with Novel β-Arrestin Antagonist Activity
ACS Medicinal Chemistry Letters·2020· 16 citedOpen Access
A Physiologically Based <i>in Silico</i> Tool to Assess the Risk of Drug-Related Crystalluria
Journal of Medicinal Chemistry·2020· 15 cited
Estimation of the Effect of OAT2-Mediated Active Uptake on Meloxicam Exposure in the Human Liver
The AAPS Journal·2020
Structural attributes influencing unbound tissue distribution
European Journal of Medicinal Chemistry·2019· 34 cited
1901-P: CK1 δ/ε Inhibitor PF-05006739 Ameliorates Hepatic Steatosis and Hyperinsulinemia in Dio Mice
Diabetes·2019
Effect of Hepatic Organic Anion‐Transporting Polypeptide 1B Inhibition and Chronic Kidney Disease on the Pharmacokinetics of a Liver‐Targeted Glucokinase Activator: A Model‐Based Evaluation
Clinical Pharmacology & Therapeutics·2019· 23 cited
Modeling Exposure to Understand and Predict Kidney Injury
Seminars in Nephrology·2019· 8 cited
Metabolism and excretion of (<i>S</i>)-6-(3-cyclopentyl-2-(4-trifluoromethyl)-1<i>H</i>-imidazol-1-yl)propanamido)nicotinic acid (PF-04991532), a hepatoselective glucokinase activator, in humans: confirmation of the MIST potential noted in first-in-Human metabolite scouting studies
Xenobiotica·2019· 2 cited
Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10–2474
ACS Chemical Biology·2019· 45 cited
Discovery of a Novel Small-Molecule Modulator of C–X–C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis
Journal of Medicinal Chemistry·2018· 24 citedOpen Access
Metabolism of PF-04958242: Substrate concentration-dependent impact of cytochrome P4503A4 inhibitors as an explanation for a lack of clinical drug–drug interaction at very low substrate doses
Drug Metabolism and Pharmacokinetics·2018
Novel Method to Predict In Vivo Liver-to-Plasma Kpuu for OATP Substrates Using Suspension Hepatocytes
Drug Metabolism and Disposition·2017· 49 cited
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Frequent Co-authors

Karen Atkinson(19), Jeffrey A. Pfefferkorn(18), Manthena V. S. Varma(14), Kevin J. Filipski(13), Meihua Tu(13), Angel Guzmán-Pérez(12), Amit S. Kalgutkar(10), Gary E. Aspnes(9), Jianwei Bian(8), Christian Perreault(8), Ayman El‐Kattan(7), David A. Tess(7), David R. Derksen(7), Charles J. Rotter(6), Bo Feng(6), Theunis C. Goosen(6), Arthur Bergman(6), Benjamin D. Stevens(6), Raman Sharma(6), Janice A. Brown(6)