Rosemary Huckvale

Materials Science · Physical Sciences

9h-index238citations20works1.02yr avg
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Research Topics

Photochromic and Fluorescence Chemistry(4), Crystallization and Solubility Studies(4), X-ray Diffraction in Crystallography(4), CAR-T cell therapy research(3), Cancer therapeutics and mechanisms(3)

Publications20 total

AI-assisted delivery of novel covalent WRN inhibitors from a non-covalent fragment screen
Bioorganic & Medicinal Chemistry Letters·2025
Computational drug discovery approaches identify mebendazole as a candidate treatment for autosomal dominant polycystic kidney disease
Frontiers in Pharmacology·2024· 2 citedOpen Access
Discovery of an <i>In Vivo</i> Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones
Journal of Medicinal Chemistry·2023· 9 citedOpen Access
CCDC 2163947: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays
Scientific Reports·2022· 8 citedOpen Access
Improved binding affinity and pharmacokinetics enables sustained degradation of BCL6 in vivo
European Journal of Cancer·2022
Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors
Journal of Medicinal Chemistry·2022· 24 citedOpen Access
Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 <i>In Vivo</i>
Journal of Medicinal Chemistry·2022· 13 citedOpen Access
Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket
Journal of Medicinal Chemistry·2021· 16 citedOpen Access
Optopharmacology reveals a differential contribution of native GABAA receptors to dendritic and somatic inhibition using azogabazine
Neuropharmacology·2020· 5 citedOpen Access
Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel
Journal of Medicinal Chemistry·2019· 28 citedOpen Access
d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity
Frontiers in Cellular Neuroscience·2017· 53 citedOpen Access
Photoactive antagonists for the GABAA receptor
UCL Discovery (University College London)·2016
Azogabazine; a photochromic antagonist of the GABA<sub>A</sub>receptor
Organic & Biomolecular Chemistry·2016· 21 citedOpen Access
Photo-antagonism of the GABAA receptor
Nature Communications·2014· 25 citedOpen Access
Asymmetric syntheses of 3,4-syn- and 3,4-anti-3-substituted-4-aminopiperidin-2-ones: application to the asymmetric synthesis of (+)-(3S,4R)-cisapride
Tetrahedron·2012· 20 cited
CCDC 845674: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
CCDC 845675: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
CCDC 845673: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
Concise, efficient and highly selective asymmetric synthesis of (+)-(3S,4R)-cisapride
Tetrahedron Asymmetry·2011· 14 cited

Frequent Co-authors

Owen A. Davis(7), Olivier A. Pierrat(7), Rachel Talbot(7), Rosemary Burke(7), Florence I. Raynaud(7), Olivia W. Rossanese(7), Benjamin R. Bellenie(7), Swen Hoelder(7), Kwai-Ming J. Cheung(6), Yann‐Vaï Le Bihan(6), Michael D. Bright(6), Angela Hayes(6), Craig McAndrew(6), Rob L. M. van Montfort(6), Alice C. Harnden(5), Alan T. Henley(5), Mirco Meniconi(5), Thomas J. A. Lorkin(5), Emma A. Gunnell(5), Alfie Brennan(4)