Olivier A. Pierrat

Institute of Cancer Research — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index650citations31works63.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Protein Degradation and Inhibitors(7), CAR-T cell therapy research(5), Cancer therapeutics and mechanisms(5), Ubiquitin and proteasome pathways(4), Protein Structure and Dynamics(3)

Publications31 total

A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death
Immunity·2024· 63 citedOpen Access
Front Cover: A Degron Blocking Strategy Towards Improved CRL4<sup>CRBN</sup> Recruiting PROTAC Selectivity (ChemBioChem 23/2023)
ChemBioChem·2023Open Access
Determination of Ligand-Binding Affinity (<i>K</i><sub>d</sub>) Using Transverse Relaxation Rate (<i>R</i><sub>2</sub>) in the Ligand-Observed <sup>1</sup>H NMR Experiment and Applications to Fragment-Based Drug Discovery
Journal of Medicinal Chemistry·2023· 19 citedOpen Access
A Degron Blocking Strategy Towards Improved CRL4<sup>CRBN</sup> Recruiting PROTAC Selectivity**
ChemBioChem·2023· 15 citedOpen Access
Discovery of an <i>In Vivo</i> Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones
Journal of Medicinal Chemistry·2023· 9 citedOpen Access
CCDC 2163947: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays
Scientific Reports·2022· 8 citedOpen Access
Improved binding affinity and pharmacokinetics enables sustained degradation of BCL6 in vivo
European Journal of Cancer·2022
Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors
Journal of Medicinal Chemistry·2022· 24 citedOpen Access
Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 <i>In Vivo</i>
Journal of Medicinal Chemistry·2022· 13 citedOpen Access
Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket
Journal of Medicinal Chemistry·2021· 16 citedOpen Access
Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1
Bioorganic & Medicinal Chemistry Letters·2021· 7 citedOpen Access
Achieving <i>In Vivo</i> Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders
Journal of Medicinal Chemistry·2020· 72 citedOpen Access
The exon junction complex senses energetic stress and regulates contractility and cell architecture in cardiac myocytes
Bioscience Reports·2017· 6 citedOpen Access
eIF4A RNA Helicase Associates with Cyclin-Dependent Protein Kinase A in Proliferating Cells and Is Modulated by Phosphorylation
PLANT PHYSIOLOGY·2016· 30 citedOpen Access
The Exon Junction Complex proteins are non‐AMP kinase dependent sensors of energetic stress and regulate contractility and sarcomere structure in cardiac myocytes
The FASEB Journal·2016
Structure of Rhomboid Protease in Complex with β-Lactam Inhibitors Defines the S2′ Cavity
Structure·2013· 34 citedOpen Access
Structure of E.coli rhomboid protease GlpG in complex with monobactam L62
2013
Structure of E.coli rhomboid protease GlpG in complex with monobactam L29
2013
Structure of E.coli rhomboid protease GlpG in complex with monobactam L61
2013
page 1 of 2Next →

Frequent Co-authors

Rosemary Burke(12), Benjamin R. Bellenie(10), Craig McAndrew(10), Rob L. M. van Montfort(10), Florence I. Raynaud(10), Swen Hoelder(10), Yann‐Vaï Le Bihan(9), Kwai-Ming J. Cheung(8), Angela Hayes(8), Owen A. Davis(8), Rachel Talbot(8), Olivia W. Rossanese(8), Michael D. Bright(7), Rosemary Huckvale(7), Alan T. Henley(6), Louise D. Johnson(5), Vladimir Kirkin(5), Jonathan M. Large(5), Matthew Freeman(5), Alfie Brennan(5)