Channa Jayawickreme

GlaxoSmithKline (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index2.0kcitations49works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(18), Chemical Synthesis and Analysis(9), Monoclonal and Polyclonal Antibodies Research(7), Biochemical Analysis and Sensing Techniques(7), Trace Elements in Health(6)

Publications49 total

Expanding the drug discovery space with predicted metabolite–target interactions
Communications Biology·2021· 22 citedOpen Access
595 Differential ligand binding distinguishes therapeutic from pathologic Aryl Hydrocarbon Receptor (AhR) modulating agents: Implications for inflammatory skin disease
Journal of Investigative Dermatology·2020· 10 cited
LB985 GSK2967901A, a novel small molecule SIRT1 activator for the topical treatment of psoriasis
Journal of Investigative Dermatology·2017· 2 cited
Identification of potent, nonabsorbable agonists of the calcium-sensing receptor for GI-specific administration
Bioorganic & Medicinal Chemistry Letters·2017· 7 citedOpen Access
Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans
Journal of Investigative Dermatology·2017· 351 citedOpen Access
Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist
Bioorganic & Medicinal Chemistry Letters·2017· 25 citedOpen Access
Identification of nonabsorbable inhibitors of the scavenger receptor-BI (SR-BI) for tissue-specific administration
Bioorganic & Medicinal Chemistry Letters·2016· 4 citedOpen Access
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)
Bioorganic & Medicinal Chemistry Letters·2014· 102 citedOpen Access
ChemInform Abstract: Synthesis and Structure—Activity Relationships of a Series of 3‐Aryl‐4‐isoxazolecarboxamides as a New Class of TGR5 Agonists.
ChemInform·2010
Synthesis and structure–activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists
Bioorganic & Medicinal Chemistry Letters·2010· 45 citedOpen Access
Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor Agonists
Journal of Medicinal Chemistry·2009· 74 citedOpen Access
A New Tool for Investigating G Protein‐Coupled Receptors
Novartis Foundation symposium·2007· 4 cited
An ILP Refinement Operator for Biological Grammar Learning
Lecture notes in computer science·2007· 7 citedOpen Access
The G-protein-coupled receptor 40 family (GPR40–GPR43) and its role in nutrient sensing
Biochemical Society Transactions·2006· 150 cited
Pertinent Background Knowledge for Learning Protein Grammars
Lecture notes in computer science·2006· 2 citedOpen Access
Functional Screening in the Melanophore Bioassay
Current Protocols in Pharmacology·2005· 4 cited
Simultaneous speciation analysis using neutron activation
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)·2004
Functional Screening of Multiuse Peptide Libraries Using Melanophore Bioassay
Humana Press eBooks·2003· 7 cited
Generation of Multiuse Peptide Libraries for Functional Screenings
Humana Press eBooks·2003· 8 cited
Going to the well no more: lawn format assays for ultra-high-throughput screening
Current Opinion in Chemical Biology·2003· 12 cited
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Frequent Co-authors

A. Chatt(11), M R Lerner(8), David Moncol(7), Thomas J. Rimele(7), Michael R. Lerner(6), Gerard F. Graminski(6), Grace Chen(4), Susan Armour(4), Chris Watson(4), Terry Kenakin(4), Steven M. Sparks(4), Karen A. Evans(4), Suresh Karne(3), James M. Way(3), Sean Ross(3), Timothy S. McClintock(3), Marc N. Potenza(3), Brian Budzik(3), David D. Wisnoski(3), Jian Jin(3)