Thomas J. Rimele

Research Triangle Park Foundation — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index2.2kcitations55works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(31), Neuropeptides and Animal Physiology(16), Nitric Oxide and Endothelin Effects(10), Veterinary Pharmacology and Anesthesia(7), Neuroscience and Neuropharmacology Research(6)

Publications55 total

Identification of potent, nonabsorbable agonists of the calcium-sensing receptor for GI-specific administration
Bioorganic & Medicinal Chemistry Letters·2017· 7 citedOpen Access
Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist
Bioorganic & Medicinal Chemistry Letters·2017· 25 citedOpen Access
Identification of nonabsorbable inhibitors of the scavenger receptor-BI (SR-BI) for tissue-specific administration
Bioorganic & Medicinal Chemistry Letters·2016· 4 citedOpen Access
Isolation and Chemical Characterization of a Neutrophil-Derived Relaxing Factor
2015· 1 cited
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)
Bioorganic & Medicinal Chemistry Letters·2014· 102 citedOpen Access
Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor Agonists
Journal of Medicinal Chemistry·2009· 74 citedOpen Access
Functional Screening in the Melanophore Bioassay
Current Protocols in Pharmacology·2005· 4 cited
1,4-Benzodiazepine Peripheral Cholecystokinin (CCK-A) Receptor Agonists
Bioorganic & Medicinal Chemistry Letters·2001· 30 cited
Foreword
Journal of Pharmacological and Toxicological Methods·1999
Use of a cell-based, lawn format assay to rapidly screen a 442,368 bead-based peptide library
Journal of Pharmacological and Toxicological Methods·1999· 25 cited
ChemInform Abstract: 3‐(2‐(N‐Phenylacetamide))‐1,5‐benzodiazepines: Orally Active, Binding Selective CCK‐A Agonists.
ChemInform·1996
Structure activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D-subtype.
Journal of Pharmacology and Experimental Therapeutics·1996· 78 cited
3-[2-(<i>N</i>-Phenylacetamide)]-1,5-benzodiazepines:  Orally Active, Binding Selective CCK-A Agonists
Journal of Medicinal Chemistry·1996· 23 citedOpen Access
Discovery of 1,5-Benzodiazepines with Peripheral Cholecystokinin (CCK-A) Receptor Agonist Activity. 1. Optimization of the Agonist “Trigger”
Journal of Medicinal Chemistry·1996· 101 citedOpen Access
Secretion of cyclic GMP by cultured epithelial and fibroblast cell lines in response to nitric oxide.
Journal of Pharmacology and Experimental Therapeutics·1995· 35 cited
CCK-A Receptor Selective Antagonists Derived from the CCK-A Receptor Selective Tetrapeptide Agonist Boc-Trp-Lys(Tac)-Asp-MePhe-NH2 (A-71623)
Journal of Medicinal Chemistry·1995· 7 citedOpen Access
BMY 7378 is a selective antagonist of the D subtype of α1-adrenoceptors
European Journal of Pharmacology·1995· 302 cited
Characterization of alpha-1 adrenoceptor subtypes in human and canine prostate membranes.
Journal of Pharmacology and Experimental Therapeutics·1994· 49 cited
Only the [3R]-enantiomer, but not the racemate, of L-365, 260 is a selective CCK-B antagonist
Appetite·1992
Rat peritoneal neutrophils selectively relax vascular smooth muscle.
Journal of Pharmacology and Experimental Therapeutics·1991· 7 cited
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Frequent Co-authors

Richard J. Heaslip(9), Daniel T. Grimes(7), Channa Jayawickreme(7), Timothy S. Gaginella(7), L L Aarhus(5), Robert J. Sturm(5), David Moncol(5), Kennedy L. Queen(5), David Grimes(5), Nicholas A. Flavahan(4), Paul M. Vanhoutte(4), Steven M. Sparks(4), Elizabeth E. Sugg(4), T. W. Rooke(4), P. M. Vanhoutte(4), Frank R. Giesa(4), Aaron S. Goetz(3), Barry M. Weichman(3), Sean Ross(3), Dallas K. Croom(3)