Paavo Honkakoski

University of North Carolina at Chapel Hill — United States

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

44h-index7.8kcitations152works2.32yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(78), Drug Transport and Resistance Mechanisms(37), Estrogen and related hormone effects(37), Hormonal Regulation and Hypertension(18), Receptor Mechanisms and Signaling(13)

Publications152 total

Functional polymorphisms in pigmentation-related genes MC1R and DCT display population-specific association with wet age-related macular degeneration
Biochemistry and Biophysics Reports·2026Open Access
Unmasking metabolic disruptors: The NEMESIS project's quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies
Open Research Europe·2025Open Access
Selection of locally administered ocular tissue-targeting RNA aptamers using in vivo SELEX
European Journal of Pharmaceutical Sciences·2025· 1 citedOpen Access
Activation of steroid hormone receptors by metabolism-disrupting chemicals
Toxicology and Applied Pharmacology·2025· 1 citedOpen Access
Look What You Made Me Do: Discerning Feature for Classification of Endocrine-Disrupting Chemical Binding to Steroid Hormone Receptors
Journal of Chemical Information and Modeling·2025· 1 citedOpen Access
Unmasking metabolic disruptors: The NEMESIS project's quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies
Open Research Europe·2024· 1 citedOpen Access
Ocular drug-metabolizing enzymes: focus on esterases
Drug Metabolism Reviews·2024· 4 cited
Filling the Blank Space: Branched 4-Nonylphenol Isomers Are Responsible for Robust Constitutive Androstane Receptor (CAR) Activation by Nonylphenol
Environmental Science & Technology·2024· 1 cited
Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD
Hepatology Communications·2024· 12 citedOpen Access
Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues
European Journal of Pharmaceutical Sciences·2023· 3 citedOpen Access
Mass spectrometry in ocular drug research
Mass Spectrometry Reviews·2023· 3 citedOpen Access
Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro
Frontiers in Pharmacology·2023· 8 citedOpen Access
Single nucleotide polymorphisms in pigmentation‐related dopachrome tautomerase and melanocortin‐1 receptor genes are associated with wet age‐related macular degeneration in a Finnish cohort
Acta Ophthalmologica·2022· 1 cited
Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates
Molecular Pharmaceutics·2022· 17 citedOpen Access
Activity and Expression of Carboxylesterases and Arylacetamide Deacetylase in Human Ocular Tissues
Drug Metabolism and Disposition·2022· 16 cited
A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity
Scientific Reports·2022· 13 citedOpen Access
Structural features affecting the selectivity of LAT1-targeted phenylalanine drug conjugates
Zenodo (CERN European Organization for Nuclear Research)·2022Open Access
Searching for Constitutive Androstane Receptor Modulators
Drug Metabolism and Disposition·2022· 17 cited
Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations
International Journal of Pharmaceutics·2021· 29 citedOpen Access
Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches
Molecular Psychiatry·2021· 52 citedOpen Access
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Frequent Co-authors

Masahiko Negishi(13), Arto Urtti(10), Olavi Pelkonen(6), Hannu Raunio(5), Matti A. Lang(5), Jenni Küblbeck(5), Johanna Jyrkkärinne(5), Mika Reinisalo(5), Tatsuya Sueyoshi(3), Jukka Hakkola(3), Marika Ruponen(3), Markku Tammi(3), Markku Pasanen(3), M. Lang(3), Maria Hytti(3), Niina Piippo(3), Kai Kaarniranta(3), Anu Kauppinen(3), Janne Mäkinen(3), Ilpo Jääskeläinen(3)