Alexandra Lenard

Children's Hospital of Philadelphia — United States

Medicine · Health Sciences

5h-index155citations12works4.32yr avg
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Research Topics

Acute Myeloid Leukemia Research(10), Protein Degradation and Inhibitors(8), Histone Deacetylase Inhibitors Research(3), Chronic Myeloid Leukemia Treatments(2), Cancer Genomics and Diagnostics(2)

Publications12 total

Upfront menin-inhibitor resistance in multiply pretreated leukemias
Experimental Hematology·2025· 2 citedOpen Access
GATA2 links stemness to chemotherapy resistance in acute myeloid leukemia
Blood·2025· 11 citedOpen Access
Aberrant Stemness Transcription Signature Unveils a Mechanism of Chemotherapy Resistance through Blunting p53-Mediated Response in Acute Myeloid Leukemia
Blood·2024
Transcriptomic without Clinical Response to Menin Inhibition As a Mechanism of Upfront Resistance in Samples from Mutliply Relapsed Patients with KMT2A-Rearranged Leukemia
Blood·2023· 1 cited
Upfront Menin-inhibitor resistance in multiply pretreated leukemias
2023· 1 citedOpen Access
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency
Molecular Cell·2021· 63 citedOpen Access
Abstract LB205: The IRF8-MEF2D transcription factor circuit regulated by a druggable multiple post-translational modification (PTM) reader ZMYND8 in acute myeloid leukemia
Cancer Research·2021
Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML
Molecular Cell·2021· 39 citedOpen Access
Menin is necessary for long term maintenance of meningioma-1 driven leukemia
Leukemia·2021· 21 citedOpen Access
Epigenetic regulation of protein translation in KMT2A-rearranged AML
Experimental Hematology·2020· 14 citedOpen Access
SWI/SNF Dysregulation through a Prion-like Domain Causes AML
Blood·2019· 3 cited
Epigenetic regulation of protein translation in <i>KMT2A</i> -rearranged AML
2019Open Access

Frequent Co-authors

Kathrin M. Bernt(12), Simone S. Riedel(10), Hongbo Xie(10), Fatemeh Alikarami‬(7), Martin Carroll(5), Junwei Shi(5), Leila Mahdavi(5), Molly C. Kingsley(4), Clara Libbrecht(4), Tobias Neff(4), Haley Goodrow(4), Gerd A. Blobel(3), Gerard M. McGeehan(3), Sarah K. Tasian(3), Sarah Skuli(3), Gerald Wertheim(3), Zhendong Cao(2), Krista A. Budinich(2), Hua Huang(2), Diqiu Ren(2)