Susanne Manhart

Serumwerk Bernburg (Germany) — Germany

Neuroscience · Life Sciences

20h-index1.8kcitations37works0.02yr avg
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Research Topics

Neuropeptides and Animal Physiology(15), Peptidase Inhibition and Analysis(15), Diabetes Treatment and Management(11), Alzheimer's disease research and treatments(7), Amino Acid Enzymes and Metabolism(6)

Publications37 total

Pharmacokinetics of ferric bepectate—a new intravenous iron drug for treating iron deficiency
Basic & Clinical Pharmacology & Toxicology·2019· 10 citedOpen Access
Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation
Neuropeptides·2016· 35 cited
Proteolytic degradation of neuropeptide Y (<scp>NPY</scp>) from head to toe: Identification of novel<scp>NPY</scp>‐cleaving peptidases and potential drug interactions in<scp>CNS</scp>and Periphery
Journal of Neurochemistry·2015· 38 citedOpen Access
A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects
Alzheimer s & Dementia Translational Research & Clinical Interventions·2015· 54 citedOpen Access
Featured Article A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects
2015
O2‐12‐05: Inhibition of glutaminyl cyclase targeting Alzheimer's disease
Alzheimer s & Dementia·2012Open Access
14 Inhibition of glutaminyl cyclase targeting neurodegeneration and neuroinflammation in Alzheimer's disease
Neurobiology of Aging·2012
Glutaminyl Cyclases Display Significant Catalytic Proficiency for Glutamyl Substrates
Biochemistry·2009· 54 cited
Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides
Biochemistry·2009· 208 cited
Isoaspartate residues dramatically influence substrate recognition and turnover by proteases
Biological Chemistry·2008
Isoaspartate containing amyloid precursor protein derived peptides alter efficacy and specificity of potential β-secretases
Biological Chemistry·2008
Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential β-secretases
Biological Chemistry·2008· 31 cited
Isoaspartate residues dramatically influence substrate recognition and turnover by proteases
Biological Chemistry·2008· 36 cited
Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat
Biochemical and Biophysical Research Communications·2007· 129 cited
Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor
Proceedings of the National Academy of Sciences·2007· 234 citedOpen Access
Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP
2007
Does human attractin have DP4 activity?
Biological Chemistry·2007· 19 cited
Prolyl Endopeptidase Cleaves the Apoptosis Rescue Peptide Humanin and Exhibits an Unknown Post-Cysteine Cleavage Specificity
Advances in experimental medicine and biology·2006· 13 cited
On the Seeding and Oligomerization of pGlu-Amyloid Peptides (<i>in vitro</i>)
Biochemistry·2006· 255 cited
Analogs of Glucose-Dependent Insulinotropic Polypeptide With Increased Dipeptidyl Peptidase IV Resistance
Kluwer Academic Publishers eBooks·2006· 25 cited
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Frequent Co-authors

Hans‐Ulrich Demuth(16), Torsten Hoffmann(14), Raymond A. Pederson(10), Ulrich Heiser(10), Hans‐Ulrich Demuth(9), Christopher H.S. McIntosh(9), Simon A. Hinke(9), Stephan Schilling(8), Kerstin Kühn‐Wache(7), Fred Rosche(6), Jens‐Ulrich Rahfeld(5), T. Hoffmann(5), S. Chambre(5), Joachim Wolfgang Bär(5), H.U. Demuth(5), Dagmar Schlenzig(4), Richard W. Gelling(4), Michael H. Engel(4), Wolfram Bode(4), Raik Wolf(4)