Pablo Huertas

Consejo Superior de Investigaciones Científicas — Spain

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index4.5kcitations101works4.52yr avg
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Research Topics

DNA Repair Mechanisms(52), CRISPR and Genetic Engineering(23), RNA Research and Splicing(16), Microtubule and mitosis dynamics(14), PARP inhibition in cancer therapy(14)

Publications101 total

miRNA-mediated cell-to-cell communications boost DNA repair during the Radioadaptative Response
2025Open Access
Circadian regulation of homologous recombination by cryptochrome1-mediated dampening of DNA end resection
Nature Communications·2025Open Access
Harnessing coumarin-thio(seleno)cyanate conjugates: potent <i>In vivo</i> antiproliferative agents targeting carbonic anhydrases
Journal of Enzyme Inhibition and Medicinal Chemistry·2025Open Access
NK-A 17E-233I: a novel competitive inhibitor of human dihydroorotate dehydrogenase (DHODH) for cancer therapy
Journal of Experimental & Clinical Cancer Research·2025Open Access
Author Correction: Mechanism of BRCA1–BARD1 function in DNA end resection and DNA protection
Nature·2025Open Access
Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity
Nature Communications·2025· 3 citedOpen Access
DNA topoisomerase IIß inhibition blocks DNA end resection and synergizes with PARPi in BRCA1-deficient models
DNA repair·2025Open Access
OA07.01 KRAS Pharmacological Blockade Elicits Tumoral Homologous Recombination Deficiency Exploitable With PARP Inhibitors
Journal of Thoracic Oncology·2025
SRSF2 overexpression induces transcription-/replication-dependent DNA double-strand breaks and interferes with DNA repair pathways to promote lung tumor progression
NAR Cancer·2025· 4 citedOpen Access
Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer
Journal of Experimental & Clinical Cancer Research·2025· 3 citedOpen Access
Asparagine endopeptidase promotes radioresistance in breast cancer through ATR pathway modulation
2025Open Access
The <scp>CDK</scp> 12– <scp>BRCA</scp> 1 signaling axis mediates dinaciclib‐associated radiosensitivity through p53‐mediated cellular senescence
Molecular Oncology·2024· 4 citedOpen Access
Author response for "The &lt;scp&gt;CDK&lt;/scp&gt;12–&lt;scp&gt;BRCA&lt;/scp&gt;1 signaling axis mediates dinaciclib‐associated radiosensitivity through p53‐mediated cellular senescence"
2024
Standardization through education of molecular pathology: a spotlight on the European Masters in Molecular Pathology
Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin·2024· 3 citedOpen Access
Mechanism of BRCA1–BARD1 function in DNA end resection and DNA protection
Nature·2024· 45 citedOpen Access
Cx43 Enhances Response to BRAF/MEK Inhibitors by Reducing DNA Repair Capacity
2024
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis
Nature Communications·2024· 12 citedOpen Access
EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells
Nucleic Acids Research·2024· 14 citedOpen Access
The signalling axis CDK12-BRCA1 mediates dinaciclib associated radiosensitivity through p53-mediated cellular senescence
2024Open Access
EXO1-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells
2024· 2 citedOpen Access
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Frequent Co-authors

Sonia Jimeno(16), Rosario Prados‐Carvajal(11), Andrés Aguilera(10), María Jesús Fernández-Ávila(7), Cintia Checa-Rodríguez(6), Fernando R. Balestra(6), Ana López-Saavedra(5), Fernando Mejías-Navarro(5), Isabel Soria‐Bretones(5), Stephen P. Jackson(4), Andrés Cruz-García(4), Rosa Luna(4), Yael Ziv(4), Yosef Shiloh(4), Marı́a Garcı́a-Rubio(4), Daniel Gómez-Cabello(4), Cristina Cepeda-García(4), Felipe Cortés‐Ledesma(3), Manuel López‐López(3), Pilar López‐Cornejo(3)